Area:
Taste & Trigeminal Systems, Development
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High-probability grants
According to our matching algorithm, Suzanne I. Sollars is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1995 — 1997 |
Sollars, Suzanne I |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Dependence of Taste Development On Receptor Innervation @ University of Virginia Charlottesville |
0.961 |
1998 — 1999 |
Sollars, Suzanne I |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Function and Organization of the Geniculage Ganglion @ University of Virginia Charlottesville
DESCRIPTION: The primary purpose of this research is to study the gustatory response properties and central terminal fields of single taste neurons of the GSP and CT nerves in the rat, nerves that innervate populations of gustatory receptors on the mammalian palate and anterior tongue, respectively. These fundamental data are lacking because of difficulty in gaining access to the ce bodies, located in the geniculate ganglion, in vivo. The principal investigat has developed a surgical preparation that provides reliable experimental acces to neurons in the geniculate ganglion. This permits neurophysiological recordings from individual GSP and CT cells to describe in detail the response properties of these intact gustatory neurons. The cells will then be injected with neuronal tracers to define the central terminal fields of the functionall characterized neurons. Together, these data will provide the opportunity to identify structure-function relationships in these primary sensory neurons. A minor component of the application is a single experiment in which integrated taste responses from the GSP nerve will be made in 12 adult rats that received bilateral transection of the CT nerve at 10 days postnatal. This study will determine whether changes in GSP activity are associated with a previously demonstrated alteration in taste preference behavior and will contribute to a line of research that investigates the long-term neurobiological consequences neonatal CT transection.
|
0.961 |
2000 |
Sollars, Suzanne I |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Function and Organization of the Geniculate Ganglion @ University of Virginia Charlottesville
DESCRIPTION: The primary purpose of this research is to study the gustatory response properties and central terminal fields of single taste neurons of the GSP and CT nerves in the rat, nerves that innervate populations of gustatory receptors on the mammalian palate and anterior tongue, respectively. These fundamental data are lacking because of difficulty in gaining access to the ce bodies, located in the geniculate ganglion, in vivo. The principal investigat has developed a surgical preparation that provides reliable experimental acces to neurons in the geniculate ganglion. This permits neurophysiological recordings from individual GSP and CT cells to describe in detail the response properties of these intact gustatory neurons. The cells will then be injected with neuronal tracers to define the central terminal fields of the functionall characterized neurons. Together, these data will provide the opportunity to identify structure-function relationships in these primary sensory neurons. A minor component of the application is a single experiment in which integrated taste responses from the GSP nerve will be made in 12 adult rats that received bilateral transection of the CT nerve at 10 days postnatal. This study will determine whether changes in GSP activity are associated with a previously demonstrated alteration in taste preference behavior and will contribute to a line of research that investigates the long-term neurobiological consequences neonatal CT transection.
|
0.961 |
2001 — 2005 |
Sollars, Suzanne I |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Plasticity in the Developing Taste System @ University of Virginia Charlottesville
The taste system develops over a prolonged period and is particularly malleable (i.e., plastic) during development. Although much is known about plasticity in other sensory systems, there is only rudimentary information about plasticity in the taste system. The overall goal of this proposal is to delineate specific morphological and functional changes to the taste system that occur after peripheral neural injury during development. The projects in this proposal build upon our recent work that describes profound alterations in peripheral and central morphology of the taste system after transection in neonatal rats of the nerves that innervate the tongue. Experiments in Aim 1 will track in vivo, degenerative and regenerative changes to the morphology of fungiform papillae after neonatal chorda tympani or lingual nerve transection. In addition, the source and pattern of the few taste buds that remain will be determined. Aim 2 will build upon our recent finding that the nerve that innervates palatal taste receptors (the greater superficial petrosal nerve) undergoes reorganization and expansion of its central terminal processes after neonatal transection of the chorda tympani nerve. Through the use of tract tracing techniques, experiments will determine the degree to which the modified greater superficial petrosal nerve invades regions of the nucleus of the solitary tract already occupied by the glossopharyngeal nerve. Aim 3 will examine the structural and functional reorganization of individual neurons of the greater superficial petrosal and the chorda tympani after neonatal chorda tympani transection. Aim 4 will determine morphological changes that occur after neonatal chords tympani transection to second-order neurons that reside in the gustatory zone of the nucleus of the solitary tract. Proposed studies will provide new information about: 1) the ability of fungiform and filiform papillae to switch phenotypes established during development, 2) the stability of the relationship between taste bud size and number of innervating neurons following severe disruption of that innervation, 3) central gustatory reorganization as it relates to interactions between different populations of afferent neurons, 4) the dynamic relationship between the structure and function of individual gustatory neurons following central reorganization, and 5) morphological changes that occur to central neurons that receive innervation from reorganized afferents. Thus, these studies will contribute not only to an understanding of taste stem plasticity, but also to an understanding of the development of nerve/target interactions.
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1 |