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Michael S. McCloskey - US grants
Affiliations: | Temple University, Philadelphia, PA, United States |
Area:
aggressionWebsite:
http://www.cla.temple.edu/psychology/faculty/michael-mccloskey/We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Michael S. McCloskey is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 2004 | Mccloskey, Michael S [⬀] | R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Emotional Information Processing &Ied: An Fmri Study @ University of Chicago The specific aim of the proposed project is to examine the relationship between neuroanatomical pathways and emotional information processing deficits among individuals with Intermittent Explosive Disorder (lED). To accomplish this goal. Two groups of individuals: 16 participants with lED and 16 participants who are free of any clinical psychopathology, will be asked to complete two tasks of emotional information processing (the emotional counting stroop and the emotional faces task) during a one-hour functional imaging session. Both tasks will be presented using a block design. Tasks will be counterbalanced across subjects. The emotional counting stroop task will consist of 1-4 words presented on a screen, to which the subject identifies how many words were shown. Four types of words are used: positive (e.g. happy, puppy), neutral (e.g. sink, chair), general negative (e.g. vomit, regret) and anger (e.g. fury, idiot). Words were selected based on previous research. Pilot research by the authors suggest that individuals with lED are slower and less accurate when anger words are shown as compared to neutral words. During the emotional faces task, participants will intermittently be shown faces with angry, neutral, fearful, or happy expressions. During the first two runs they will be asked to identify the gender of the face presented using two 2-button response panels on their right hand. During the latter two runs participants will be asked to note the emotional expression of the pictures, but will not be asked to make a response. Past research has shown that individuals with a number of clinical disorders (e.g. Borderline Personality Disorder, Major Depression) exhibit an impaired ability to identify some types of emotional faces. Participants will then identify the emotional faces outside of the fMRI environment. Recently it has been demonstrated that lED patients are less accurate in identifying emotional faces than control subjects. It is hypothesized that lED subjects will (1) be less accurate at the emotional stroop tasks than control subjects when anger words are presented, (2) be less accurate at identifying emotional faces than control subjects, and (3) show a differential pattern of brain activation to emotional faces and words including increased amygdala activation for fear words and faces and decreased orbitofrontal activity for anger words and faces. |
0.961 |
| 2004 — 2005 | Mccloskey, Michael S [⬀] | R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Validation of a Laboratory Measure of Self-Aggression @ University of Chicago [unreadable] DESCRIPTION (provided by applicant): Research in the areas of suicide and self-aggression has traditionally relied on non-experimental methodologies (e.g., case studies and correlational findings). Though useful in identifying correlates of lethal and non-lethal acts of self-aggression, these methodologies are unable to specify causality. A similar problem with aggression research was addressed via the use of laboratory analogues of aggression. However, early attempts at creating a laboratory analogue of self-aggression were methodologically flawed, and no studies have been published using a laboratory measure of self-aggression for almost 20 years. The proposed investigation will assess the validity of a newly developed laboratory measure of self-aggression, using a largely clinical population. Participants will consist of 108 individuals with a DSM-IV Borderline Personality Disorder (BPD) and 27 psychopathology-free control participants with no past self-aggressive behavior. Participants with a BPD will be placed in one of four groups based on their history of suicidal behavior (past attempts vs. no past attempts) and non-suicidal self-injurious behavior (SIB vs. no SIB). All participants will complete self-report and interview measures. Some measures will assess risk factors for self-aggression (e.g., depression, hopelessness, impulsivity), while others will assess unrelated constructs (e.g., competitiveness, social desirability). Increased platelet serotonin (5-HT)-2a receptor binding has been found to be positively correlated with suicidal behavior. Therefore, blood will be drawn to assess platelet 5- HT-2a receptor density. Participants will then begin the self-aggression paradigm (SAP) in which they will compete against a fictitious opponent. Prior to each of the SAP trials, participants will select the level of shock they will receive if they lose that trial. Shock settings will range from no shock to a shock level the participant believes is twice what they previously stated was very unpleasant. Construct validity for the SAP would be evidenced by: (1) significantly higher mean and maximum self-selected shocks among groups with a history of self-aggressive behaviors, (2) significant correlations between self-selected shocks on the SAP and other known correlates of self-aggression, (3) non-significant differences for self-selected shock between the BPD and non-BPD groups with no history of self-aggressive behaviors, and (4) non-significant correlations between self-selected shock and constructs unrelated to self-aggression. [unreadable] [unreadable] |
0.961 |
| 2006 — 2008 | Mccloskey, Michael S [⬀] | K23Activity Code Description: To provide support for the career development of investigators who have made a commitment of focus their research endeavors on patient-oriented research. This mechanism provides support for a 3 year minimum up to 5 year period of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators. |
Individual Cognitive-Behavioral Psychotherapy For Ied @ University of Chicago [unreadable] DESCRIPTION (provided by applicant): Intermittent Explosive Disorder (IED) is increasingly acknowledged as a common, potentially disabling psychiatric condition. Despite this, there are currently no empirically supported behavioral treatments for patients with IED. The purpose of the proposed study is to assess the short-term and long-term efficacy of a cognitive-behavioral treatment (CBT), previously found to be successful in treating dysfunctional anger, for treating IED. Secondary goals of the project are to (a) explore mechanisms involved in the successful treatment of IED, and (b) examine individual differences associated with treatment response. This request for a Patient-Oriented Mentored Scientist Award (K23) serves to cultivate the candidate's research acumen as it relates to randomized clinical trials, advanced biostatistical methodologies, and cognitive neuroscience. Ninety subjects meeting criteria for both current research and current DSM IED criteria will be randomly assigned to either 12 weeks of CBT or 12 weeks of a supportive psychotherapy control condition. Subjects will be assessed before and after therapy as well as at 6 month and 12 month follow-up. Primary outcome measures will assess aggressive behavior, anger, and the presence of an IED diagnosis at post-treatment, 6-month follow-up and 12-month follow-up. Social and emotional information processing will be evaluated as potential mechanism of change. Trait aggression will be assessed as a potential moderating variable. [unreadable] [unreadable] [unreadable] |
0.961 |
| 2008 — 2009 | Mccloskey, Michael S [⬀] | R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Effects of Acute Alcohol Intoxication On Physically Aggressive Behavior in Women @ University of Chicago [unreadable] DESCRIPTION (provided by applicant): Aggression is a worldwide public health problem, with devastating effects to perpetrators, victims, and society, and with associated costs of over 100 billion dollars in the U.S. alone. Alcohol is the drug that is most commonly linked to violent behavior, with the majority of serious violent acts (e.g., homicide) occurring under the influence of alcohol. Despite correlational research showing interpersonal violence occurs across gender, laboratory studies of aggression (which rely almost exclusively on community/college samples) have failed to demonstrate alcohol-facilitated physical aggression for women. In contrast, laboratory studies have repeatedly shown that alcohol facilitates aggression in men who are high in trait aggressiveness and/or low in executive functioning (i.e., planning, reasoning, response inhibition). The proposed project will compare the physically aggressive behavior of clinically aggressive (as defined by a current diagnosis of Intermittent Explosive Disorder [IED]; N=75) and control (healthy volunteer: N=75) women after administration of either (a) approximately 0.90g/kg (adjusted for BMI) of alcohol, (b) an active placebo drink, or (c) a clearly marked non-alcoholic drink. The study will occur over 2 days. On day 1, subjects will complete a diagnostic evaluation, related measures, and an executive functioning battery that includes: trails B, Stroop task, conditional associative learning task, Wisconsin card sort task, porteus maze and the go nogo task. On day 2, subjects will consume the alcohol/placebo/no-alcohol drink, then complete a laboratory task of physical aggression - the Taylor Aggression Paradigm (TAP) approximately 20 minutes after cessation of drink consumption. Aggression on the TAP is defined as the intensity of shock the subject administers to a (unbeknownst to the subject) fictitious opponent. It is hypothesized that alcohol will facilitate aggression only for women in the IED condition, and that alcohol-facilitated aggression would be moderated by executive functioning. Furthering our understanding of the inter-relationship between history of physical aggression, executive functioning, and alcohol-facilitated aggression in women will help guide development of intervention programs for aggressive women and spur additional research into models of alcohol-facilitated aggression in women. [unreadable] [unreadable] The proposed project will compare the physically aggressive behavior of clinically aggressive (as defined by a current diagnosis of Intermittent Explosive Disorder [IED]) and control women after administration of either approximately 0.90g/kg of alcohol, an active placebo drink, or a clearly marked non-alcoholic drink. [unreadable] [unreadable] [unreadable] |
0.961 |
| 2010 — 2014 | Mccloskey, Michael S | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cognitive Behavioral Aggression Treatment: Effects On Brain and Behavior @ Temple Univ of the Commonwealth DESCRIPTION (provided by applicant): Aggressive behavior is a leading worldwide public health problem costing tens to hundreds of billions of dollars annually in terms of medical care and lost productivity. The human cost is equally great, creating distress and suffering in the aggressor, their victim, loved ones and society as a whole. Despite this there are currently no empirically supported treatments for pathological affective (hostile) aggression. A rich literature suggests that aggression is associated with impaired socio-emotional information processing, which is governed by a prefrontal-limbic circuit in the brain. This is supported by studies of affectively aggressive subjects showing increased amygdala response and decreased orbitomedial prefrontal response to negative socio-emotional stimuli such as angry facial expressions or negative evocative pictures. A goal of cognitive behavioral therapy is to reduce dysfunctional socio- emotional information processing. Preliminary data by the PI suggests a 12- session cognitive behavioral aggression treatment may be efficacious in reducing aggressive behavior and underlying cognitive (socio-emotional information processing) and biological (cortico-limbic activation) deficits associated with affective aggression. To assess the efficacy of this treatment, 120 subjects with clinically relevant affective aggression would be randomized to either the cognitive-behavioral aggression treatment or a supportive psychotherapy control. All subjects will monitor their aggressive behavior throughout the active treatment phase using ecological momentary assessment (EMA). Subjects would also complete self-report and behavioral of both aggression and social-emotional information processing and pre-treatment and post-treatment, then again at 6-month and 1-year follow-up. To assess the effect of the cognitive behavioral treatment on cortico-limbic functioning, subjects would complete two social information processing tasks (identifying the emotional valence of faces and evocative pictures) while undergoing functional Magnetic Resonance Imaging (fMRI) at pre-treatment and again at post- treatment. It is hypothesized that relative to supportive psychotherapy, the cognitive behavioral aggression treatment will result in decreased aggressive behavior and improved socio- emotional information processing as well as decreased amygdala/increased orbitomedial prefrontal activation to socio-emotional stimuli. |
0.928 |
| 2010 — 2014 | Coccaro, Emil Frank [⬀] Mccloskey, Michael S (co-PI) [⬀] |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Ssris and Self-Harm in Borderline Personality Disorder @ University of Chicago DESCRIPTION: Suicide and lesser forms of intentional self-harm behaviors produce devastating medical, social and economic costs. Self-harm is integrally related to depressive disorders and Borderline Personality Disorder. Selective Serotonin Reuptake Inhibitors (SSRIs), like escitalopram, are front-line pharmacological treatments for these disorders, putatively regulating depressed mood and reducing suicidality. However, data from case studies and retrospective meta-analyses of depression clinical trials is mixed, with some (but not all ) studies suggesting that during the first months of treatment, SSRIs may increase the risk of suicidal ideation in select individuals, particularly younger individuals. These post-hoc analyses, though informative, are based on studies that provide limited sampling of the self-harm domain. No study, to date, has implemented a direct prospective examination of the effects of early SSRI use on self-harm thoughts and behaviors using a multi-method measurement involving both the laboratory (standard self-aggression paradigm: SAP) and home environments (ecological momentary assessment: EMA). Also, no study has examined the influence of impaired 5-HT function and emotion dysregulation as moderators of outcome with escitalopram. The proposed randomized clinical trial will prospectively assess the impact of eight weeks exposure to SSRI treatment on self-harm ideation and behavior among a sample of 200 subjects with Borderline Personality Disorder and current major depression. After a one week single-blind placebo lead-in, participants will be randomly assigned double blind to either placebo or escitalopram for eight (8) weeks. The primary dependent variable will be EMA of self-harm ideation and behavior obtained several times each day. Self-harm will also be assessed using a laboratory analogue task (SAP) at baseline and again after the eight week trial. Age will be evaluated as a moderator of SSRI response. 5-HT dysfunction and emotion dysregulation will be evaluated as candidate moderators of SSRI response. 5-HT functioning will be assessed using psychophysiological (loudness dependence of the auditory evoked potential: LDAEP) and genetic (5-HT transporter promoter polymorphism: 5-HTTLPR) markers. Measures of emotion dysregulation will include trait aggression, impulsivity and socioemotional information processing. At the conclusion of the eight-week randomized trial, all participants will receive eight weeks of escitalopram administered single-blind, with continued EMA and other assessment. |
0.961 |
| 2021 | Mccloskey, Michael S | R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Validation of An Fmri Measure of Real Time Non-Suicidal Self-Injury @ Temple Univ of the Commonwealth Non-suicidal self-injury (NSSI), the direct and deliberate destruction or alteration of body tissue without suicidal intent, is a major public health issue that can lead to severely disabling outcomes including permanent physical injuries and recurrent hospitalizations. Furthermore, NSSI and related acts of produce a great societal cost, with medical treatment and lost productivity alone summing to approximately $33 billion dollars per year. Neuroimaging studies also show cortico-limbic differences between individuals with and without a history of NSSI the on tasks of emotion regulation and physical pain, most notably the prefrontal cortex and amygdala. However, to date no studies have directly examined the neurocircuitry of in-vivo NSSI behavior. This is in large part due to the dearth of fMRI tasks of in-vivo NSSI. The Self Aggression Paradigm (SAP) is a behavioral NSSI task that uses self-selected shock as an NSSI analogue. In addition to being one of the very few validated NSSI behavioral tasks, the SAP is the only NSSI analogue in which both the decision to self-harm as well as the intensity of self-harm is completely under the control of the participant, as it is in actual NSSI. The SAP has been used to identify the causal relationship between putative risk factor for NSSI (e.g. alcohol intoxication, depression, serotonin depletion) and self-harm. To address the need to directly study brain mechanisms involved in NSSI and changes in NSSI in real time, the research team has developed an fMRI version of the SAP. The study proposed in this application would allow us to (1) assess the validity of the fMRI-SAP and (2) conduct a pilot examination of neural activation and connectivity patterns associated with real time self-harm among individuals with (and without) a clinically significant NSSI history. Thirty participants with NSSI disorder (NSSI+: n= 30) and 30 matched participants with no history of NSSI (NSSI+: n =30) will complete a clinical interview assessing psychopathology (including NSSI disorder) followed by self-report measures of NSSI- related risk factors and a behavioral measure of pain tolerance. Participants will then undergo a brief mood induction to acutely increase negative affect (a common antecedent of NSSI) followed by functional neuroimaging during the fMRI SAP. We hypothesize that NSSI participants will select higher shocks on the fMRI SAP and that among those with NSSI, the level of self-shock will correlate with NSSI severity (evidence of fMRI?SAP validity). We also hypothesize there will be decreased prefrontal and increased amygdala activation as well as decreased orbitofrontal-anterior cingulate and orbitofrontal-amygdala connectivity for NSSI+ (vs NSSI-) participants on shock trials on the fMRI-SAP. |
0.928 |