2008 — 2009 |
Wong, Maria M. |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Sleep Problems and Substance Use/Abuse in Adolescence and Young Adulthood
[unreadable] DESCRIPTION (provided by applicant): This proposed research project is the PI's first R21 submission. The project aims at articulating the relationship between sleep problems (SPs) and substance use/ problems in adolescence and young adulthood. Research in adults indicates that insomnia predicts subsequent onset of substance abuse. Several cross-sectional studies suggest that SPs are positively related to substance use in adolescence. However, only a few prospective studies exist on the relationship between insomnia and alcohol use earlier in life. So far the data indicate SPs are related to onset of substance use in boys but not in girls. In response to PA-06-238, the current proposal seeks funding to support secondary data analysis from the Michigan Longitudinal Study (MLS). The project has four specific aims. First, we examine whether earlier sleep problems prospectively predict onset of substance use in adolescence and young adulthood. Second, we test whether earlier sleep problems prospectively predict escalation in substance use and abuse once onset begins. Third, we examine potential mediators of the relationship between sleep problems and substance use. Three mediators will be examined - behavioral problems, peer group choices, and neurophysiological arousal. Fourth, we evaluate how perceived stress may moderate the relationships between sleep problems and substance use. We are especially interested in possible gender differences related to these four aims. The Michigan Longitudinal Study is an ongoing family study currently in its 19th year. The study recruited a community sample of alcoholic and control families. Male and female offspring of these families have been interviewed from preschool age (3-5 years old) to young adulthood (18-21 years old) at 3-year intervals. Participants were also interviewed at yearly intervals from ages 11 to 17. Information regarding SPs and all other variables was collected at each wave. Data on substance use were gathered from the participants beginning at age 9. This project has the potential to document another, more physiologically proximal mechanism related to those affect and behavioral indicators already known to be central in the emergence of substance use and problems. This is the first work of its kind, and if successful, would lead to more elaborated studies on the effects of sleep problems on substance use and affect regulation. [unreadable] [unreadable] [unreadable]
|
0.958 |
2013 — 2017 |
Wong, Maria M. |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Sleep Physiology and Risk For Alcohol Problems in Children of Alcoholics
DESCRIPTION (provided by applicant): This proposed project is a resubmission of the PI's first R01 application. Alcohol-dependent individuals have well-described disturbances of sleep, but whether these sleep disturbances precede or follow heavy, problem drinking is unknown. Several lines of evidence across the human life span now suggest that sleep disturbances may precede and represent a marker of risk for the development of alcohol use disorders. For instance, there appears to be a longitudinal relationship between sleep problems, alcohol use, and alcohol use disorders in both adolescents and adults. Very few studies, however, have systematically examined the sleep patterns, habits, and architecture of biological children of an alcohol- dependent parent (COAs), who already are at increased risk both to drink earlier than their peers and to have an early onset of alcohol use disorders. A longitudinal investigation of sleep parameters in relation to risk for early onset of alcohol use and alcohol related problems among COAs and controls (non-COAs) would clarify the influence of sleep disturbances and potentially inform prevention and early intervention efforts. The current proposal seeks funding to support a longitudinal study on sleep patterns, architecture, and regulation in COAs and controls. Specific aims are: (i) to examine the sleep patterns, habits, and architecture of COAs and controls over time via multiple measures of sleep, including self-report, parental ratings, actigraphy, and polysomnography; (ii) to understand the effects of sleep disturbances on neurocognitive functions, behavioral problems, and risk for early alcohol use/abuse among COAs and controls; and (iii) to understand how gender, pubertal development, and perceived stress may moderate the relationship between sleep problems and alcohol use/abuse among COAs and controls. A three-wave longitudinal design is proposed. Participants will be 8-12 years old at Time 1, 9-13 years old at Time 2, and 10-14 years old at Time 3. Multiple measures of sleep, including actigraphy and polysomnography data will be collected at Time 1. At Times 2 and 3, actigraphy will be repeated and data on self-report and parental ratings of sleep, as well as neurocognitive functions and behavioral problems will be gathered. Information regarding onset of alcohol and other drug use, as well as related problems will also be collected at Times 2 and 3. This project has the potential to document the relationships among sleep problems, family history of alcoholism, neurocognitive functions, behavioral problems, and the development of alcohol problems among COAs and controls. Results of the study will lead to practical information on the relationship between sleep problems and alcohol use disorders, with implications for prevention and early intervention.
|
0.958 |