| 2004 |
Lin, Jack J |
P41Activity Code Description:
Undocumented code - click on the grant title for more information. |
Extrahippocampal Structural Abnormalities in Epilepsy @ University of California Los Angeles
brain morphology; epilepsy; hippocampus; biomedical resource; clinical research;
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0.938 |
| 2005 — 2011 |
Lin, Jack J |
P41Activity Code Description:
Undocumented code - click on the grant title for more information. |
Extrahippocampal Structural Abnormalities in Mesial Temporal Lobe Epilepsy @ University of California Los Angeles
model design /development
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0.938 |
| 2006 — 2008 |
Lin, Jack J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Effects of Seizures On White Matter Tracts and Behavior @ University of California San Diego |
0.938 |
| 2008 — 2010 |
Lin, Jack J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Predictors of Differential Vulnerability to Anxiety and Depression Is Epilepsy: @ University of California San Diego
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1. Hypothesis: Elevated salivary cortisol levels reliably predict increased anxiety or depression levels and decreased QOL. HPA axis function will be evaluated with quantitative assays of salivary cortisol levels and related to neuropsychological measures of anxiety, depression, and QOL.AIM 2. Hypothesis: Elevated cortisol levels compromise structural volume and integrity (e.g. mean anisotropy and mean diffusivity) in limbic circuits associated with the HPA axis. Using neuroimaging techniques, structural volumes and indices of structural integrity (e. g. Fractional Anisotropy and Mean Diffusivity) in limbic circuits will be correlated with salivary cortisol levels in order to elucidate structural changes associated with HPA axis dysregulation. AIM 3. Hypothesis: Changes in structural volume and integrity in limbic circuits induced by elevated cortisol levels underly cognitive deficits and psychiatric symptoms of anxiety and depression. Using neuroimaging techniques, structural volumes and indices of structural integrity in limbic circuits will be correlated with measures of cognitive performance in order to determine cognitive sequelae of structural changes associated with elevated cortisol levels.
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0.938 |
| 2009 — 2013 |
Lin, Jack J |
K23Activity Code Description:
To provide support for the career development of investigators who have made a commitment of focus their research endeavors on patient-oriented research. This mechanism provides support for a 3 year minimum up to 5 year period of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators. |
Early-Onset Epilepsy and Genetics Influence White Matter Tracts and Cognition @ University of California-Irvine
DESCRIPTION (provided by applicant): Project Summary: This project will explore the relationship between white matter integrity and cognitive dysfunction in individuals with temporal lobe epilepsy (TIE). Although TLE is associated with deficits in multiple cognitive domains, the neurobiological basis underlying these deficits is unclear. A potential mechanism is epilepsy-induced abnormal connections (white matter tracts) between multiple brain regions that are involved in complex cognitive function. Diffusion tensor imaging (DTI) is a magnetic resonance sequence that measures the structural integrity of white matter tracts and thus is an extremely useful tool for investigating brain connections. In Aim 1, I will use DTI to probe the integrity of white matter tracts in individuals with TLE. In Aim 2, I will correlate DTI indices of white matter integrity with specific neuropsychological measures. In Aim 3, I will prospectively examine the relationship between the changes in white matter integrity, as measured by DTI, and the development of cognitive deficits in children with TLE. Significant linkage between white matter integrity and cognitive function will support DTI as a useful biomarker for the development of cognitive deficits. This proposal utilizes advanced brain imaging techniques to uncover the biological basis of cognitive dysfunction in individuals with epilepsy. New insights from the study may enable us to target candidates for cognitive intervention and for potential prevention of epilepsy-related cognitive deficits. I am a dedicated Clinician/Scientist who is fully committed to a career in epilepsy research. I have received protected time and full support from the Neurology Department and the School of Medicine at the University of California, Irvine, a world-renowned center for neurosciences and a recognized center for basic and clinical epilepsy research. In the training portion of the proposal, I will receive training in clinical design, biostatics, bioethics, neuropsychological testing, as well as state-of-the-art neuroimaging techniques. My ultimate goal is to combine clinical and research efforts to understand the neurobiological basis of cognitive dysfunction in people with epilepsy and to develop potential preventive strategies. Relevance: Epilepsy is a brain disorder that affects 1% of the American population and is associated with significant cognitive (i.e. memory and language) problems. This proposal will use advanced brain imaging techniques to study the relationship between abnormal brain connections and cognitive problems. Better understanding of cognitive problems in individuals with epilepsy may lead to improved treatment options.
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0.958 |