We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Ling Bai is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2021 |
Bai, Ling |
K99Activity Code Description: To support the initial phase of a Career/Research Transition award program that provides 1-2 years of mentored support for highly motivated, advanced postdoctoral research scientists. |
Sensory Mechanisms Underlying Metabolic Regulation @ University of California, San Francisco
PROJECT SUMMARY Animals have a remarkable ability to restore metabolic homeostasis after a challenge to their internal state. In order to maintain energy balance after a meal, the composition and quantity of ingested food needs to be closely monitored to coordinate the physiological responses of visceral organs. Dysregulation of this process leads to metabolic disease like obesity and diabetes. However, how sensory signals of nutritional state are detected and processed to generate metabolic commands is poorly understood. Vagal sensory neurons innervate the gut and are poised to detect diverse interoceptive cues. My postdoctoral work in Dr. Zachary Knight's lab has generated a cellular map of vagal sensory neurons that links their molecular identity to their target organ innervations and putative gut signals. This work provided a roadmap for the use of genetic tools to manipulate vagal subtypes with high specificity. In the mentored phase of this grant, I will build upon my postdoctoral discoveries by investigating how vagal sensory neurons regulate autonomic responses to achieve metabolic homeostasis (Aim 1). These mentored experiments will allow me to gain deep understanding of metabolic regulation and autonomic physiology, as well as to acquire additional surgical skills to manipulate the GI tract. The target of vagal neurons is the nucleus tractus solitarius (NTS), a key metabolic center that integrates neural and circulating humoral signals and generates complex physiological and behavioral commands to maintain energy balance. In the independent phase of this grant, I will build upon my graduate and postdoctoral training to further investigate how the downstream neuronal circuits in the NTS integrate and process interoceptive signals, and how they generate output commands to drive metabolic responses (Aim 2 and Aim 3). This grant will allow me to expand my current experimental and intellectual skills and develop additional expertise in metabolic regulation as well as electrophysiology guided circuit mapping, under the guidance of my advisory committee who are expertise in those fields. This will further link my sensory neurobiology skillset to the study of physiologic function and advance my career goal of being an independent researcher.
|
1 |