Area:
HIV; Mental Health, Global Mental Health; Human mobility
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High-probability grants
According to our matching algorithm, Holly R. Campbell is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1997 — 2000 |
Campbell, Holly R |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Neural Basis of Form Perception in a Model Visual System
This proposal investigates the neural basis of orientation and form perception by a non-vertebrate model system, the dipteran Phaenicia sericata. The research will identify visual parameters pertinent to low-level form vision using behavioral tests. It will then employ these parameters as stimuli for testing the filter properties of identified neurons in a neuropil having neuroanatomical characteristics analogous to mammalian visual cortex. To understand mechanisms of visual perception, investigations at the single cell level must be performed against a background of detailed morphological analysis such that the structure of single neurons responding to specific visual stimuli can be related to the overall neuroanatomical context of the system. The dipteran compound eye and optic lobes offer an ideal substrate for such an investigation. The optic lobes' succession of retinotopically organized neuropils is functionally analogous to organization amongst mammalian visual regions, but contains orders of magnitude fewer neurons. In particular, the planned research will focus on the lobula, a neuropil supplied by the parvicellular element of this visual system and containing within it nerve cells that are structurally analogous to pyramidal and stellate neurons of mammalian cortex. The relative simplicity of this model system facilitates the identification of single computational units and allows detailed circuit analysis A further advantage of this simple system is that it reflects evolutionarily conserved principles of visual system design that cut across phylogenetic boundaries. The proposed will investigate: . the ability of a dipteran species to discriminate visual patterns and shapes containing orientation and texture information. . the cellular properties of neurons and circuits in the lobula that discriminate orientations and textures. . the anatomical organization of pyramidal-like and stellate-like neurons in the dipteran lobula.
|
0.904 |
2001 — 2003 |
Campbell, Holly R |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Activity and Plastic Effects of Parallel Fibers @ Oregon Health and Science University
This study will investigate the physiological properties of descending inputs to a primary sensory neuropil and the plasticity within this structure that highlights behaviorally significant sensory inputs. The proposed research will be performed in the electrosensory lateral line lobe (ELL) of mormyrid electric fish, a cerebellum-like structure in the medulla. The ELL acts as an adaptive filter in which predictable electrosensory inputs, such as those which are self-generated, are removed from the electrosensory processing stream. The probable mechanism is that of plasticity in the effects of predictive signals conveyed by parallel fibers. Specific Aim 1 will determine the activity of ELL parallel fibers by recording from the granule cells that give rise to them. Responsiveness of these cells to naturally occurring predictive signals, such as motor commands and proprioceptive signals, will be tested. Specific Aim 2 will examine the responses of ELL cells to these naturally-occurring predictive signals conveyed by parallel fibers, with a focus on plastic change following a period of association with peripheral electrosensory stimuli. The results of the project will be relevant to the general issues of descending control of sensory processing, storage of sensory information, and cerebellar function.
|
0.913 |