We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, David Koren is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2015 — 2018 |
Koren, David |
F30Activity Code Description:
Individual fellowships for predoctoral training which leads to the combined M.D./Ph.D. degrees. |
Mechanism of Neurotransmitter Co-Release in a Retinal Circuit
? DESCRIPTION (provided by applicant): Retinal direction-selective ganglion cells (DSGCs) respond selectively to motion in one direction. Recent work has shown that these cells send information to visual cortex, suggesting that they may influence conscious vision, yet the fundamental mechanisms underlying retinal direction selectivity are still not clear. Starburst Amacrine Cells (SACs) are thought to control direction selectivity by preferentially releasing GABA on one side of DSGCs. However, SACs also release acetylcholine in a symmetric manner. Although neurotransmitter co- release at other synapses has been shown to play a role in disorders such as depression, it is unknown how release of two transmitters can be differentially modulated. The main question this proposal aims to address is how SACs release these two neurotransmitters in different distributions. We will use a combination of patch- clamp electrophysiology, optogenetics, and imaging to examine the presynaptic and postsynaptic specifications that may contribute to these differences. We will also use pharmacology and calcium imaging to examine how co-release of GABA and acetylcholine is modulated and how it functions in this particular circuit. The results of this work will clarify the function of this behaviorally important sensory circuit, with potential implications for restoring vision. In additin, because of the increasingly recognized importance of neurotransmitter co-release in other areas of the brain, this study will have implications for the general understanding of chemical transmission in the nervous system.
|
1 |