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High-probability grants
According to our matching algorithm, Rajeev I. Desai is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2009 — 2010 |
Desai, Rajeev Indrajit |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Nicotinic Modulation of Methamphetamine's Behavioral and Neurochemical Effects
DESCRIPTION (provided by applicant): This R21 application responds to PA-07-227, which describes an urgent need for a greater understanding of the underlying neurobiological and behavioral mechanisms in the addictive effects of methamphetamine (MA) and cocaine. The use and abuse of MA and cocaine is a major public health concern world-wide;despite significant effort to identify indirectly and directly acting dopamine (DA)-based candidate medications as potential agonist-based treatments, no effective pharmacotherapies are yet available for the management of addiction to MA and cocaine. As non-dopaminergic mechanisms, including nicotinic systems, also may contribute importantly to the addictive effects of these psychomotor stimulant drugs, the study of non- dopaminergic ligands, including nicotinic drugs, may lead to novel 'agonist-based'candidate medications. Based on reports in the scientific literature and our own preliminary results, nicotinic agonists can interfere with the expression of behavioral and neurochemical effects of MA, and therefore, may be suitable 'agonist-based'candidate medications for stimulant abuse and addiction. To evaluate this medication strategy, we propose to determine whether the prototypic agonist nicotine (NIC) attenuates the abuse-related behavioral and neurochemical effects of MA in a primate species. Using established methods to study the discriminative- stimulus and observable effects of dopaminergic drugs, we plan to directly analyze how acute or chronic (15- day) treatment with nicotine may alter behavioral effects of MA. Drug discrimination studies will be conducted in monkeys prepared with dialysis cannulae targeting either the striatum or prefrontal cortex. During drug testing, dialysate samples will be removed and analyzed for DA level. These coordinated studies will allow a comprehensive assessment within the same test session of how the behavioral and neurochemical effects of MA may be modified by nicotinic agonist treatment. The results of these studies will provide important information regarding the potential therapeutic value of nicotinic-based medication strategies for the management of abuse and addiction to MA and related stimulants. The proposed research also should lead to further studies to identify novel nicotinic targets to help combat MA addiction. PUBLIC HEALTH RELEVANCE: Methamphetamine abuse and addiction has emerged as a major public health concern, and effective treatments with which to help manage this problem have not yet been identified. This project is designed to study the potential therapeutic value of nicotinic-based medication strategies. The proposed research will lead to a greater understanding of the mechanisms responsible for methamphetamine addiction and may identify novel nicotinic targets to help combat methamphetamine addiction.
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2012 — 2015 |
Desai, Rajeev Indrajit |
K01Activity Code Description: For support of a scientist, committed to research, in need of both advanced research training and additional experience. |
Drug Abuse Methodology: Training and Interdisciplinary Application
DESCRIPTION (provided by applicant): This K01 application responds to PA-10-056, and is intended to obtain support and protected time for Dr. Rajeev I. Desai (PI) to gain extensive supervised research training and experience in all aspects of intravenous (IV) self-administration methodology in non-human primates (NHP). The project is designed to systematically allow the PI to acquire necessary skills and experience to independently and expertly study the reinforcing effects of stimulant and other addictive drugs, and to couple this methodology with concurrent in vivo microdialysis to measure related neurochemical activity. The support provided by the K01 award will ultimately allow the PI to: a) develop a comprehensive program of highly translational neurochemical and behavioral studies to directly address the public health concern of stimulant addiction and the development of medications for its treatment; and b) acquire the tools necessary to independently continue and expand this line of research through R01 funding mechanisms. The aims of this project are designed to optimize the PI's training experience through a systematic series of experiments evaluating IV cocaine and nicotine self- administration behavior under simple and complex schedules of reinforcement. The PI next will couple his existing expertise with in vivo microdialysis techniques to his newly acquired behavioral skills to measure changes in striatal dopamine levels produced by cocaine and nicotine during IV self-administration performance under different schedule conditions. Finally, studies will be conducted to determine whether nicotinic agonist-based candidate medications attenuate reinforcing and neurochemical effects of self- administered nicotine or cocaine. The proposed research in this project will establish the PI as a well-trained and independent young scientist who is qualified to conduct highly translational addiction research in NHP. In addition, the planned studies may lead to the further development of promising novel nicotinic-based pharmacotherapy to help combat the scourge of stimulant addiction that plagues our public health. PUBLIC HEALTH RELEVANCE: Translational behavioral and neurochemical methodologies are an integral part of drug addiction research methodology, and there is a clear need for trained scientists who are qualified to conduct this type of multi- dimensional work in nonhuman primates. This project is designed to systematically provide a young investigator with intensive supervised research training to directly measure the reinforcing effects of addictive drugs and their associated neurochemical changes in highly translational procedures. The proposed research will lead to a greater understanding of neurochemical mechanisms in psychomotor stimulant addiction, and may identify novel nicotinic targets to help combat this public health concern.
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