We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Kyle Ketchesin is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2019 |
Ketchesin, Kyle |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Role of Molecular Rhythms in the Nucleus Accumbens and Dorsal Striatum in Schizophrenia @ University of Pittsburgh At Pittsburgh
PROJECT SUMMARY/ABSTRACT Schizophrenia (SCZ) is a debilitating psychiatric disorder affecting more than 20 million people worldwide and is a leading cause of disability. Notably, a prominent feature of SCZ is disturbances in circadian rhythms, including altered sleep/wake cycles and disrupted peripheral gene expression and hormone rhythms. While altered peripheral and behavioral rhythms have been implicated in SCZ, it is currently unknown whether molecular rhythms are altered in the human brain, particularly in regions of the cortex and striatum thought to be associated with core symptoms of the disease. Recent studies from our group and others have demonstrated circadian rhythms in gene expression in the human brain by utilizing a ?time of death? (TOD) analysis of postmortem brain tissue, in which gene expression data is organized across a 24-hour clock based on the subject?s time of death. Li and colleagues (2013) performed a TOD analysis of microarray data and found subjects with major depressive disorder show altered rhythms in a variety of cortical and limbic regions. Using a similar approach, our group identified significant gene expression rhythms in the human prefrontal cortex (PFC) and discovered changes in rhythmicity that occur with aging. Preliminary studies from our group have recently extended these findings into psychiatric disease cohorts. Using a TOD analysis of RNA sequencing data from the dorsolateral PFC, we find SCZ subjects have completely different sets of rhythmic genes and a distinct pattern of rhythmic transcripts compared to controls. In this proposal, I aim to study molecular rhythms in two regions of the striatum, the dorsal striatum (DS) and nucleus accumbens (NAc). Alterations in dopamine functioning in the striatum are associated with positive symptoms and psychosis in SCZ. Notably, dopamine acts via striatal dopamine receptors to regulate rhythmic expression of core circadian clock genes in the striatum, suggesting that altered dopamine signaling in SCZ could influence molecular rhythms in the striatum, which may play a role in the circadian abnormalities observed in SCZ. In this proposal, I will first use human postmortem brain tissue to compare gene expression rhythms in the DS and NAc of SCZ versus healthy control subjects. Mice will then be used as an experimental system to determine the functional relevance of molecular rhythms in each of these regions. Given the role of dopamine in regulating striatal rhythmicity, I hypothesize that SCZ subjects will exhibit significant disruptions in molecular rhythms in the DS and NAc compared to control subjects. In mice, I hypothesize that disrupting striatal rhythms will promote SCZ-relevant behaviors. Together, these studies will be the first to measure molecular rhythms in the human striatum of SCZ subjects and are central to understanding how rhythm disruptions in the striatum are linked to disease state. A better understanding of the role of molecular rhythms in SCZ may lead to novel targets for future drug development.
|
0.948 |