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High-probability grants
According to our matching algorithm, John N. Fain is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1988 |
Fain, John N |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hormonal Control of Lipid Metabolism
thyroid hormones; somatotropin; catecholamines; insulin; lipid metabolism; hormone regulation /control mechanism; pertussis vaccine; hypothyroidism; adenylate cyclase; triacylglycerol lipase; glucocorticoids; glucose metabolism; atherosclerosis; bacterial toxins; lipolysis; alpha antiadrenergic agent; phosphatidylinositols; norepinephrine; guanine nucleotides; cyclic AMP; gel electrophoresis; adipocytes;
|
1 |
1985 |
Fain, John N |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Insulin and Catecholamine in Carbohydrate Metabolism @ University of Tennessee Health Sci Ctr
The project is designed to investigate the regulation of glycogen phosphorylase in isolated rat hepatocytes by hormones with particular emphasis on insulin and alpha catecholamines. Alpha catecholamines and vasopressin are thought to activate phosphorylase secondary to an elevation of intracellular calcium. Our interests relate to the nature of the alpha-adrenergic receptors which appear to be of the alpha1 rather than alpha2 category for all metabolic effects of alpha catecholamines. We are interested in the relationship between the increased turnover of phosphatidylinositol seen in hepatocytes after the addition of vasopressin and catecholamines and the elevation of cytosol calcium. There is evidence that phosphatidylinositol turnover is not increased secondary to entry of extracellular calcium. However, the link between these two events remains to be established. We are currently testing the hypothesis that increased turnover of phosphatidylinositol is involved in the primary events which result in the release of bound intracellular calcium and the uptake of extracellular calcium.
|
0.988 |
1987 — 1991 |
Fain, John N |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hormonal Regulation of Phosphoinositide Metabolism @ University of Tennessee Health Sci Ctr
The aim of these studies is to examine the hormonal regulation of phosphoinositide metabolism in rat hepatocytes and other cells. In liver, alpha-1 catecholamines and vasopressin activate glycogen phosphorylase secondary to an elevation of intracellular calcium and diacylglycerol. The rise in calcium is secondary to formation of inositol 1,4,5 trisphosphate derived from phospholipase C-induced breakdown of phosphatidylinositol 4,5- bisphosphate (PIP2) as is diacylglycerol. It is now clear that phospholipase C activity is regulated by guanine nucleotides. This project focuses on the role of guanine nucleotides in hormone induced breakdown of phosphatidyl-inositol 4,5- bisphosphate. Our long-term goal is isolation of the membrane bound phospholipase C responsible for breakdown of phosphoinositides. The requirement for guanine nucleotides suggests that a guanine nucleotide binding protein, tentatively called Np, may be involved in coupling of hormone-receptor complexes to phospholipase C. Phospholipase C activity will be examined using tritiated PIP2. We will attempt to label Np with GTP analogues and find a toxin that will ADP-ribosylate it, with the eventual aim of isolating this putative guanine nucleotide binding protein. Investigations will continue on the regulation by agonists that stimulate polyphosphoinositide breakdown, of high affinity GTPase activity in hepatocytes and other cell types. We intend to establish the identity of the guanine nucleotide binding protein involved. The inhibition by vasopressin of hepatocyte (Ca2+ Mg2+) ATPase activity will be further investigated in an attempt to elucidate the link, if any, between this effect and phosphoinositide breakdown. This project is primarily a metabolic investigation using biochemical techniques. The studies are done in experimental animals and should provide significant insights into various diseases of metabolism and especially diabetes.
|
0.988 |