We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Matthew Decker is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2017 — 2020 |
Decker, Matthew |
F30Activity Code Description:
Individual fellowships for predoctoral training which leads to the combined M.D./Ph.D. degrees. |
Local and Systemic Regulation of Hematopoietic Stem Cells by Thrombopoietin @ Columbia University Health Sciences
Project Summary: Hematopoietic stem cells (HSCs) are a critical and rare population of cells that can self- renew extensively and produce all blood cell lineages. HSCs are maintained and regulated throughout life by extrinsic regulation; disruption of this regulation can lead to loss of HSCs and hematopoietic failure. Thus, understanding HSC extrinsic regulatory mechanisms has important therapeutic implications. Thrombopoietin (TPO) is a hematopoietic cytokine that is canonically understood as a driver of megakaryocyte proliferation and platelet production, but has also been shown to be required for HSC maintenance. However, since TPO is made in the bone marrow, the liver and other tissues, the relative contributions of local and systemic TPO to HSC function are still unknown. This project aims to characterize the in vivo role of TPO in HSC biology by use of two novel mouse models that allow identification of TPO+ populations in the bone marrow, and conditional deletion of Tpo from select tissues. The experiments in this proposal will define the role of TPO in HSC biology, and have major implications for clinical therapies that take advantage of our novel understanding of how HSC regulation is balanced between local and systemic factors.
|
1 |