We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, MacDonald J. Christie is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1986 |
Christie, Macdonald J |
F05Activity Code Description: To provide collaborative research opportunities for qualified non-immigrant alien scientists who hold a doctoral degree or its equivalent in one of the biomedical or behavioral sciences. |
Opiate Tolerance in Single Brain Neurones in Vitro @ Massachusetts Institute of Technology |
0.909 |
2000 — 2002 |
Christie, Macdonald J |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Opioid Withdrawal Mechanisms in Midbrain Neurons
DESCRIPTION: (Adapted from the Investigator's Abstract) Chronic use of opioids results in tolerance and physical dependence. Both processes are due to adaptive changes in neurons resulting from continued exposure to agonists. However, the neuronal mechanisms underlying physical dependence, characterized by a rebound excitation on withdrawal of agonists, remain poorly understood. Several brain regions including the periaqueductal gray (PAG) are thought to play a pivotal role in expression of physical dependence on opioid drugs. The goal of the proposed studies is to determine the ionic and second messenger mechanisms causing physical dependence in single PAG neurons. In particular, we propose to: Further characterise opioid modulated ionic conductances, particularly voltage activated potassium and nonselective cation conductances in mouse PAG neurons to inform studies of adaptations following chronic morphine treatment. Characterise the processes of tolerance to opioid agonists for the various ionic conductances modulated by mu opioid receptors in mouse PAG neurons. Characterise the ionic currents underlying excitation of mouse PAG neurons during opioid withdrawal. Identify key adaptations to second messenger systems underlying the changes found in Aim 3) using modulators of second messenger systems and genetically modified mice. Characterise the changes in GABAergic and glutamatergic synaptic transmission that occur during withdrawal excitation in mouse PAG. Identify key adaptations to second messenger systems underlying the changes found in Aim 5) using modulators of second messenger systems and genetically modified mice.
|
1 |