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High-probability grants
According to our matching algorithm, Valerie L. Kilman is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2001 |
Kilman, Valerie L |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Do Real Stimuli Better Evoke Backpropagation and Ltp? @ Northwestern University
Neuronal action potentials are electrical signals that travel along the axon to induce release of chemical neurotransmitters at synapses. However, action potentials also backpropagate into dendrites, the branching input structures of neurons. Though its role is not fully understood, backpropagation undoubtedly affects dendritic signal processing in important ways. Understanding dendritic signal processing is critical to a full understanding of normal learning and memory, which includes changes in dendrites and dendritic inputs, and diseases involving dendritic dysfunction such as epilepsy, some forms of mental retardation, Parkinson's disease, and others. This proposal explores the possibility that spike trains with realistic, irregular timing may be more effective at generating backpropagation and long term potentiation (LTP), the primary model of learning and memory, than the artificial regular spike trains that are generally used to induce it experimentally. Initial experiments will test which type of spike train stimulated in hippocampal CAI pyramidal neurons backpropagates more efficiently into the dendrite: real, irregular spike trains taken from in vivo experiments or regular spike trains of the same overall frequency. The role of various frequency components of the spike trains in backpropagation efficiency will be tested. Next calcium imaging of the CA1 dendrites will determine if real inputs result in more calcium influx, necessary to LTP induction, than artificial inputs. Lastly, LTP will be generated at the Schaffer collateral-CA1 synapse by pairing trains of subthreshold synaptic stimuli with matched spike trains in the CA1 pyramidal soma. The amount of LTP induced by real, irregular and artficial, regular spike trains will be compared. These experiments will test the hypothesis that physiological back ro a ation is more effective and supports LTP more readil than commonly-used regular stimuli.
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2005 — 2009 |
Kilman, Valerie L |
K01Activity Code Description: For support of a scientist, committed to research, in need of both advanced research training and additional experience. |
Induction of the Molecular Circadian Clock @ Northwestern University
DESCRIPTION (provided by applicant): The principal investigator is a Research Assistant Professor in Northwestern University's Center for Sleep and Circadian Biology. She seeks training in the molecular genetics of circadian rhythms to complement her current skills. Her long-term goal is to study circadian rhythms and their development. Circadian rhythms are predictable daily changes in behavior and physiology. Driven by an internal biological clock, they have profound clinical relevance to diagnosis and treatment of disease and to sleep and affective disorders. The core of all known circadian clocks is a cell-autonomous transcriptional feedback loop, well-conserved between Drosophila and mice. In both species a central component is the Clock (Clk) gene. In flies its ectopic expression induces ectopic circadian clocks. The immediate research goal of this proposal is to determine the role of the Clock gene in organizing these molecular oscillations, a defining step in clock development. Specifically, genetic requirements for clock induction in Drosophila will be tested with ectopic CIk expression in mutants for genes that regulate or partner with CLK, and by misexpression of these other clock genes. A developmental requirement for CIk in organizing endogenous clocks will be examined by conditional rescue of Clk at various developmental times using molecular genetic approaches. The generality of these results will be tested by determining if transgenic expression of the mouse Clock gene is able to induce ectopic clocks in mice. The studies will be conducted at Northwestern University under the mentorship of and in collaboration with an internationally renowned mammalian geneticist (J. Takahashi) and a rising young fly geneticist (R. Allada). Here, the Center for Sleep and Circadian Biology provides a stimulating and dynamic environment for training in biological rhythms. In conjunction with a didactic program and individual mentoring, the [candidate] will gain training and experience in the molecular genetics of circadian rhythms in fly and mouse models. These techniques will complement her anatomical skills. In addition, training in the field of circadian rhythms will allow synthesis of many aspects of her previous work which include vertebrate and invertebrate studies on the ontogeny of networks underlying behavior. It is expected that this will allow her to develop into a mature circadian researcher studying the development of the biological clock.
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