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High-probability grants
According to our matching algorithm, Shaina M. Short is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2017 — 2018 |
Short, Shaina Marie |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Inhibitory Mechanisms of Odor Intensity Processing in the Olfactory Bulb
Project Summary/Abstract Subpopulations of inhibitory interneurons are hypothesized to control mechanisms of information processing in the brain, such as gain, tuning, normalization, and sensitivity, yet across neural systems, the unique roles of inhibitory cell types remain unclear and largely unstudied. As in all sensory systems, the olfactory bulb must conduct stimulus intensity coding, because without the ability to process odorant intensity, animals are unable to effectively forage, mate, and avoid predation, resulting in decreased survival rates and diluted social interactions. This work expands on previous in vitro experiments and tests predictions from computational neural circuit models for the first time in vivo. New two-photon imaging techniques will be optimized to assess inhibitory (periglomerular) and excitatory (mitral and tufted) cell intensity response functions simultaneously in vivo in the same anesthetized or awake animal and the same glomerulus during stimulation with the same panel of odorants. This new method will reduce data variability that arises when conducting experiments and comparing data across different animals, neural circuits, and odorant stimulations. This proposal will enable direct and novel comparisons across different cell populations. This proposal will also establish the unique roles of two inhibitory interneuron populations (periglomerular and granule cells) in shaping excitatory mitral and tufted cell responses during awake odor intensity dependent processing. Recently published methods for subtype specific expression of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) will be applied in this proposal to manipulate periglomerular and granule cell inhibition in awake mice while they sample odorants varying in intensity. This proposal will elucidate fundamental circuit mechanisms and the roles of inhibitory interneurons used in odor intensity dependent processing in the olfactory bulb.
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1 |
2020 — 2021 |
Short, Shaina Marie |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Establishing Patterns of Dopamine Signaling in the Olfactory Bulb
PROJECT SUMMARY/ABSTRACT Dopamine is known to control mechanisms of information processing throughout the brain, including gain control, tuning, and sensitivity modulation. The role of dopamine signaling is particularly important in the olfactory bulb since there is a dense population of dopaminergic local interneuron and dopamine receptors are expressed on nearly all cell types. Behaviorally, pharmacological manipulations of dopamine receptor activity is known to influence odor discrimination and detection thresholds. However, where, when, and how in vivo dopamine release shapes neural circuit function to process odor information is not well understood. Building upon earlier in vitro experiments, this proposed work tests predictions about patterns of dopamine release in the olfactory bulb in vivo for the first time using cutting edge genetically encoded optical probes to monitor dopamine release. Spatiotemporal patterns of odor-evoked dopamine transmission in awake mice will be monitored to assess how stimulus intensity, frequency and experience-dependent plasticity shape dopamine transmission in the olfactory bulb. Experiments will test the levels of dopaminergic interneuron activity required to trigger dopamine release. In addition to measuring dopamine release, I will use a novel dual-color imaging approach to capture both dopamine transmission and dopaminergic interneuron dynamics simultaneously during awake odor processing.
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1 |