Area:
spinal cord injury, neuroscience, immunology
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High-probability grants
According to our matching algorithm, Ona E Bloom is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2010 |
Bloom, Ona |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Pilot Study: the Role of Mif in Spinal Cord Injury @ Feinstein Institute For Medical Research
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our long-term goal is to develop therapeutics that improve spinal cord function after injury. The objective of this protocol is to determine if levels of macrophage migration inhibitory factor, a highly conserved pro-inflammatory cytokine, are elevated in spinal cord injury (SCI) patients and test the effects of a neutralizing MIF compound on samples from SCI patients in vitro.
|
0.915 |
| 2012 — 2013 |
Bloom, Ona |
R03Activity Code Description:
To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Transcriptome Analysis of a Regenerating Vertebrate Spinal Cord After Injury @ Feinstein Institute For Medical Research
DESCRIPTION (provided by applicant): Spinal cord injury (SCI) is a devastating malady for which there is no cure. The long-term goal of this project is to identify the molecular mechanisms necessary and sufficient to accomplish successful functional recovery after SCI in humans. The ability to regenerate and recover function after injury in the nervous system varies widely across species. The lamprey is a jawless vertebrate with a nervous system that shares many fundamental traits with mammals at the organizational, cellular and molecular levels. However, unlike mammals, lampreys exhibit the remarkable ability to spontaneously regenerate severed axons in their spinal cord and recover function after SCI. As a first step towards our long-term goal, the aims of this project are to obtain the gene expression profile of the central nervous system of uninjured lampreys, and over the time course of their anatomical and functional recovery. These data will provide the essential discovery platform to determine, in an unbiased manner, a set of genes potentially relevant to successful recovery from SCI. Next, as inflammation inhibits recovery from SCI in humans, and little is known about the regulation of inflammation in species that recover after SCI, we will identify immune response genes expressed in lamprey following SCI and over the time course of their anatomical and functional recovery. We will also examine effects on the lamprey's gene expression profile over the time course of anatomical and functional recovery induced by post- SCI treatment with an anti-inflammatory, neuroprotective steroid. By comparison to data obtained from other species, both more and less regenerative, we will identify pathways conserved across regenerative species or absent from less regenerative ones, such as mammals. In summary, this project will provide information critical to generating testable hypotheses on how to promote functional recovery after SCI in biological settings where this remains a challenge, such as in humans. PUBLIC HEALTH RELEVANCE: The long-term goal of this research is to identify molecular factors that promote successful recovery from spinal cord injury (SCI). The goal of this project is to discover the genes expressed during successful anatomical and functional recovery after SCI in the lamprey, an animal that can accomplish this robustly. The insights gained in this study will help us to understand how to promote these processes in other species, such as humans.
|
0.915 |