We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Jen-Wei Lin is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1987 — 1988 |
Lin, Jen-Wei |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Depolarization Release Coupling in T-Fiber Synapse |
0.961 |
1994 — 1998 |
Lin, Jen-Wei |
R29Activity Code Description: Undocumented code - click on the grant title for more information. |
Release Mechanism and Plasticity At a Tonic Synapse @ Boston University Medical Campus
DESCRIPTION: (Adapted from the applicant's abstract) Synaptic transmission is the mechanism by which neurons communicate with each other. Synapse forms the link between neurons in a neuronal network and its plasticity certainly would have a profound effect on the network and animal behavior. However, this basic cellular mechanism is still poorly understood at a molecular level. This grant proposes to investigate short term plasticities and characteristics of tonic transmitter release in the crab T-fiber synapse. In the nervous systems of invertebrates and vertebrates, tonic synaptic transmission is associated with graded presynaptic depolarizations. The most notable example of tonic synapses in vertebrates is that between photoreceptors and secondary neurons in retina. The presence of dendrodendritic synapses have been reported in olfactory bulb, thalamus, motor cortex, and other areas of vertebrate central nervous system. Synaptic contact between dendrites presumably also have the potential of utilizing graded and tonic mode of transmitter release. The release processes of tonic synapses have not been investigated in depth mostly because of technical difficulties. The T-fiber preparation is technically advantageous for the investigation of tonic transmitter release because double electrode presynaptic penetration enables one to achieve a precise control of presynaptic membrane potential. In addition, this synapse expresses robust potentiation. The control of presynaptic potential also allows one to analyze potentiated release quantitatively. The proposed experiments are divided into three parts: (1) Quantitative characterization of tonic transmitter release, (2) Characterization of potentiated transmitter release, and (3) Modulation of tonic and enhanced transmitter release by second messenger systems.
|
1 |
1999 — 2003 |
Lin, Jen-Wei |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Plasticity At a Crayfish Neuromuscular Synapse
DESCRIPTION: (Applicant's Abstract) We propose to use the inhibitory synapse of the crayfish neuromuscular junction to investigate mechanisms underlying synaptic plasticity with a presynaptic voltage control method. This method allows us to use presynaptic steps of defined duration and amplitude, rather than action potentials, to activate transmitter release. With this method, we have been able to separate two mechanisms that increase transmitter output downstream of calcium influx. The first one accelerates transmitter release kinetics and the second mechanism increases the number of available vesicles. We have shown that synaptic facilitation only utilizes the former while okadaic acid (OA) and serotonin can activate both mechanisms. In addition, the accelerated release kinetics is accompanied by a reduction in the calcium cooperativity of transmitter release. These observations forrn the bases of the pro osed studies outlined here. We propose to use the presynaptic voltage control method to investigate physiological mechanisms underlying long term facilitation (LTF) and second messenger, protein kinase A and C (PKA and PKC). mediated synaptic enhancement. Our preliminary data show that LTF increases the number of available vesicles without changing release kinetics. Results from this study should provide new insights to the physiological conditions under which a specific presynaptic mechanism can be selectively activated. In addition, since it has been shown that the kinase A pathway underlies LTF, we also propose to perform kinetics analysis of transmitter release mediated by PKA and PKC. Our working hypothesis is that PKA and PKC may modulate vesicle availability and release kinetics, respectively. This series of studies should provide new insights to the relative importance of individual kinase pathways on different forms of synaptic plasticity. We also propose to use calcium imaging techniques to measure changes in calcium cooperativity associated with different forms of synaptic plasticity. Since we have shown that accelerated release kinetics during facilitation is accompanied by a reduction in cooperativity, we sought to measure the cooperativity, with imaging techniques, under a different condition where an obvious acceleration in release kinetics has been shown. Our preliminary data show that calcium cooperativity decreases in OA. We propose to examine calcium cooperativity during LTF, in OA, and in PKA and PKC activated synaptic enhancement. Our working hypothesis is that decreased cooperativity will only be observed under conditions that accelerate release kinetics and not under those that increase the vesicle availability. Changes in calcium cooperativity add a new facet to our thinking of synaptic plasticity.
|
1 |