1985 |
Krasne, Franklin B |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Escape Behavior: Integratin and Plasticity @ University of California Los Angeles
The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the crayfish escape response repertoire, which consists of a small set of escape responses all of which are subject to habituation and probably also to other forms of plastic modification. Specific behavioral and electrophysiological research is proposed on (1) cellular mechanisms of associative learning, (2) effects of neuron activity on synapse formation and maintenance, and (3) the neural circuitry that is responsible for generating escape behavior and for integrating it with the overall behavior of the animal.
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1 |
1986 — 2000 |
Krasne, Franklin B |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Escape Behavior Integration and Plasticity @ University of California Los Angeles
The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the lateral giant escape reaction circuit of the crayfish, which is subject to a variety of forms of control and modulation. Behavioral, electrophysiological, and anatomical research is proposed on (1) the cellular basis of sensitization, long-term potentiation, and associative learning, (2) modulatory circuitry that is involved in integrating lateral giant escape into the behavioral repertoire of the animal, and (3) effects of neural activity on synapse formation during regeneration following injury.
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1 |
1989 — 2005 |
Krasne, Franklin B |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Escape Behavior--Integration and Plasticity @ University of California Los Angeles
The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the lateral giant escape reaction circuit of the crayfish, which is subject to a variety of forms of control and modulation. Behavioral, electrophysiological, and anatomical research is proposed on (1) the cellular basis of sensitization, long-term potentiation, and associative learning, (2) modulatory circuitry that is involved in integrating lateral giant escape into the behavioral repertoire of the animal, and (3) effects of neural activity on synapse formation during regeneration following injury.
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1 |
1994 — 1997 |
Macklin, Wendy Krasne, Franklin Feldman, Jack (co-PI) [⬀] Beatty, Jackson Ellison, Gaylord (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
From Molecules to Mind: the Ucla Laboratory For the 21st Century @ University of California-Los Angeles
9451080 Beatty This proposal seeks funds to enrich the undergraduate neuroscience laboratory experience at UCLA by extending current exercises and experiments into the domain of the neuron and the genome. Two new neuroscience laboratories -the Interdisciplinary Neuroscience Laboratory and the Behavioral Neuroscience Laboratory -will benefit from the grant. The requested instrumentation will give students experience in intracellular microelectrode recording from cultured Aplysia neurons, the source of much basic knowledge of neuronal function; patch-clamp recording from PC-12 and N1E1-15 cells studying ion channels and receptors; and restriction analysis of DNA and DNA sequence analysis for identifying a series of clones that are expressed primarily in the brain. Patch-clamp and molecular biological methods will bc used together to study the properties of expressed receptors, channels, pumps, and other important membrane proteins in the Xenopus oocyte system. All these exercises are at the forefront of contemporary neuroscience and technically are well within the grasp of university undergraduates. Both the departmental and the interdisciplinary neuroscience laboratories are team taught, with each faculty member teaching a module in his or her own area of expertise. Up to date documentation and instructional material for all laboratory modules will be made available to all colleges and universities over Internet.
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0.915 |