| 1998 — 2021 |
Singer, Elyse J |
P41Activity Code Description:
Undocumented code - click on the grant title for more information. R24Activity Code Description:
Undocumented code - click on the grant title for more information. U01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. U24Activity Code Description:
To support research projects contributing to improvement of the capability of resources to serve biomedical research. |
National Neurological Aids Bank @ University of California Los Angeles
DESCRIPTION (provided by applicant): This application represents the renewal of the UCLA National Neurological AIDS Bank (NNAB) for an additional 5 years of funding to carry out the resource and research activities of the Bank. Since 1998, NNAB has provided human tissues, fluids, and data for research into the causes and treatment of Neuro-AIDS. NNAB has recruited a racially, ethnically, and linguistically diverse cohort distinctive to and representative of the greater Los Angeles, CA area. We have successfully conducted a longitudinal study of persons with advanced AIDS and HIV-seronegative controls. These subjects have agreed to undergo serial clinical examinations, to donate their blood, urine, and cerebrospinal fluid during their lives, and to donate their tissues and organs after their deaths. A group of subjects also receives separately funded longitudinal magnetic resonance imaging/magnetic resonance spectroscopy scans that add further scientific value to the cohort. Between 2002 and mid-2007 we filled 68 unique requests comprised of tissue and fluids to AIDS researchers worldwide. NNAB also collects information about co-morbid conditions that interact with HIV in the pathogenesis of neurological and psychiatric disorders, and investigates the best methods to detect cognitive impairment in our HIV+ minority subjects. Herein, we describe our new research agenda. We have taken the lead in plans for NNTC co-morbidity research, that will increase the value of the NNTC samples by adding data on aging, hepatitis, metabolic and cardiovascular disorders, tobacco use, adherence, use of non-HIV medications, and by enriching the substance abuse data collected. We have recruited 2 new members to the Scientific Leadership Group who offer expertise in epidemiology and Neuro-AIDS clinical studies. We have developed studies to better diagnose neurocognitive disorders in our diverse cohort, to search for host-genetic markers of AIDS-related neurological and psychiatric disorders, and we have increased our collaborations with investigators who study neurovirology, genetics, toxicity of HIV drugs, and substance abuse. NNAB offers an invaluable resource and research asset to the scientific community and to people afflicted by Neuro-AIDS. Lay Language Summary: The NNAB study recruits and examines donors with AIDS and other diseases. Volunteers agree to donate medical information and samples of their body fluids during their lives, and their tissues and organs after their deaths. This tissue is distributed to worthy scientists for the purpose of medical research. NNAB also conducts its own research into the diagnosis, causes, and cures for neurological diseases associated with HIV infection, such as HIV dementia, myelopathy, peripheral neuropathy, myopathy, psychiatric disorders, and medication toxicity in HIV patients. Part A:
|
0.958 |
| 2003 — 2007 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. R24Activity Code Description:
Undocumented code - click on the grant title for more information. |
National Neurological Aids Bank (Nnab) @ University of California Los Angeles
[unreadable] DESCRIPTION (provided by the applicant): [unreadable] [unreadable] This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with AIDS and HIV-seronegative subjects, who have agreed to be examined and to donate blood, urine, and cerebrospinal fluid (CSF) during their life, and their organs and tissues after death. NNAB collects and distributes these tissues to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes subjects using NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve standardized diagnoses monitored by NNTC Quality Assurance Committees. NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C Virus (HCV) infection, hypertension, diabetes, lipid disorders and other metabolic abnormalities, and HIV neurological disease. The NNAB cohort is extraordinarily diverse, reflecting the gender, ethnic and racial distribution of AIDS in Los Angeles. NNAB has 84% male, 15% female, and 1% transgender subjects; over 60% of this sample consists of racial and ethnic minorities; 20% are monolingual in Spanish, 20% are over age 50, and 10% have less than a 6th grade education. In this renewal, NNAB plans to expand our cohort by collaborations with investigators at University of Hawaii who have many Asian-Pacific subjects, and the Charles R Drew University of Medicine and Science, which is rich in African-American and women subjects. NNAB has developed independent projects studying CSF viral load, HCV and the nervous system, and Magnetic Resonance Spectroscopy (MRS). These projects further enrich the value of our specimens. NNAB continues to provide an increasingly important resource that mirrors the changing face of AIDS, and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable contribution to the NNTC, the scientific community, and people living with HIV/AIDS. [unreadable] [unreadable]
|
0.958 |
| 2004 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
National Neurological Aids Bank(An R 24, Research Resource Observational, Lon... @ University of California Los Angeles
AIDS /HIV neuropathy; tissue resource /registry; HIV infections; patient /disease registry; comorbidity; tissues; blood; cerebrospinal fluid; urine; clinical research; human subject;
|
0.958 |
| 2004 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Phase Ii, Placebo-Controlled, Double-Blind Study of the Selegiline Transderma... @ University of California Los Angeles
transdermal drug delivery; human therapy evaluation; cognition disorders; deprenyl; MAO inhibitors; mental disorder chemotherapy; HIV infections; drug screening /evaluation; clinical trial phase II; longitudinal human study; medical complication; AIDS dementia complex; patient oriented research; clinical research; human subject;
|
0.958 |
| 2005 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Hiv/Cns Tissue Network (Aka National Neurological Aids Bank) @ University of California Los Angeles |
0.958 |
| 2005 — 2006 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Phase Ii, Placebo-Controlled, Double-Blind Study of the Selegiline Transderma @ University of California Los Angeles |
0.958 |
| 2008 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Double-Blind Study of Minocycline in the Treatment of Hiv-Associated Cognitive @ University of California Los Angeles
2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-; 3-mononitrotyrosine; 3-nitrotyrosine; 4 hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal; 4-hydroxynonen-2-al; AIDS Virus; Apoptosis; Apoptosis Pathway; Blood; CCL2; CCL2 gene; CRISP; Cell Death, Programmed; Ceramide (lipids); Ceramides; Cerebrospinal Fluid; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Computer Retrieval of Information on Scientific Projects Database; Disturbance in cognition; Double-Blind Method; Double-Blind Study; Double-Blinded; Double-Masked Method; Double-Masked Study; Functional impairment; Funding; GDCF-2; GDCF-2 HC11; Gene Products, RNA; Grant; HC11; HIV-1; HIV-I; HIV1; Human immunodeficiency virus 1; Immune Markers; Immunodeficiency Virus Type 1, Human; Immunologic Markers; Impaired cognition; Individual; Institution; Investigators; MCAF; MCP-1; MCP1; MGC9434; Minocycline; Monocyte Chemoattractant Proteins; Monocyte Chemotactic Proteins; NIH; National Institutes of Health; National Institutes of Health (U.S.); Oxidative Stress; Proteins; RNA; RNA, Non-Polyadenylated; Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; Ribonucleic Acid; SCYA2; SMC-CF; Source; Sphingomyelins; United States National Institutes of Health; Week; cognitive dysfunction; cognitive loss; cognitively impaired; functional disability; gene product; human T cell leukemia virus III; human T lymphotropic virus III; improved; nitrotyrosine; spinal fluid
|
0.958 |
| 2009 |
Singer, Elyse J |
M01Activity Code Description:
An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Phase Ii, Randomized, Placebo-Controlled Study of Hiv Cognitive @ University of California Los Angeles
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: Primary Objective " To examine whether minocycline treatment for 24 weeks improves HIV-associated cognitive impairment. Secondary Objectives " To examine whether minocycline treatment for 24 weeks is safe and well-tolerated in individuals with HIV-associated cognitive impairment. " To examine whether minocycline treatment for 48 weeks is safe and well-tolerated in individuals with HIV-associated cognitive impairment. " To examine whether minocycline treatment for 24 weeks improves functional impairment. " To examine whether minocycline treatment for 24 weeks decreases levels of several markers of HIV-associated cognitive impairment including, but not limited to, HIV-1 RNA;a marker of immune activation, [monocyte chemoattractant protein (MCP-1)];a marker of apoptosis (sFas);markers of oxidative stress [ceramide, sphingomyelin, 4-hydroxynonenal (HNE), and 3-nitrotyrosine [3-NT] modified proteins] in blood and cerebrospinal fluid (CSF).
|
0.958 |