We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Michelle L. Price is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1998 — 1999 |
Price, Michelle L |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Corticotropin-Releasing Factor and Serotonin Interaction @ University of Pennsylvania
DESCRIPTION: The dorsal and median raphe nuclei, the source nuclei of forebrain serotonergic innervation, contain corticotropin releasing factor (CRF) receptor mRNA and are densely innervated with CRF-immunoreactive fibers. Taken with recent findings that demonstrate biphasic effects of CRF on striatal serotonin (5-HT) release and inhibitory effects of CRF on neuronal activity of putative 5-HT neurons in the dorsal raphe nucleus, it is possible that CRF, or a related family member, regulates the activity of the 5-HT system. The objective of this proposal is to examine the physiological interactions between the brain CRF system and the raphe nuclei serotonergic system. Since CRF and 5-HT have been independently implicated in stress and stress-related psychiatric disorders, such as depression and anxiety, we hypothesize that interactions between CRF and 5-HT may be important in mediating the effects of particular stressors. This hypothesis will be tested by the following specific aims: 1) Determine the local mechanism of CRF control of 5-HT release. Pharmacological analysis using CRF receptor agonists and antagonists will be performed. These studies will be used to determine whether CRF-5-HT interactions occur at the level of 5-HT cell bodies. 2) Determine whether CRF effects on forebrain 5-HT release are regionally specific. Dose-response curves for the effects of CRF, administered intracerebroventricularly on 5-HT release in lateral septum, amygdala, nucleus accumbens, and hypothalamus will be generated. 3) Determine physiological conditions during which endogenous CRF affects the forebrain 5-HT system. The ability of a CRF receptor antagonist to block alterations in 5-HT release in terminal regions during physiological stressors will be determined. This aim will provide functional significance for CRF-5-HT interactions and reveal situations in which endogenous CRF interacts with the forebrain 5-HT system.
|
1 |