Jagadeesh Sridhara Rao

Affiliations:	2014		NIH (NIA)
	1994-1998	Neurochemistry	NIMHANS, Bengaluru, Karnataka, India
	1999-2001	Department of Psychiatry	University of Illinois at Chicago, Chicago, IL, United States

Area:

Serotonergic receptors, glutamergic receptors, neuroinflammation, exitotoxicity, Epigenetics,

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"Jagadeesh Rao"

Bio:

Rao JS*, Keleshian VL, Klein S, and Rapoport SI.modifications in the frontal cortex of Alzheimer's disease and bipolar disorder patients. Transl Psychiatry, 3 July 2012; 2: e132. doi: 10.1038/tp.2012.55.
2. Kim, H-W, Rapoport, SI, and Rao, JS* Altered expression of apoptotic factors and synaptic markers in bipolar disorder patients' postmortem brains.Mar 2010;37(3):596-603.
3. Taha AY, Cheon Y, Ma K, Rapoport SI, Rao JS. Altered fatty acid concentrations in the prefrontal cortex of schizophrenic patients J Psychiatr Res. May 2013;47(5):636-43.
4. Primiani CT, Ryan VH, Rao JS, Cam MC, Ahn K, Modi HR, RapoportCoordinated gene expression of neuroinflammatory and cell signaling markers in the dorsolateral prefrontal cortex during human brain development and aging. PLoS One, October 20, 2014, 9(10): e110972.
5. Reese EA, Cheon Y, Ramadan E, Kim HW, Chang L, Rao JS, Rapoport SI, Taha AY. Gabapentin's minimal action on brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder. Prostaglandins Aug-Sep 2012;87(2-3):71-7.
6. Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients, according to Kim H-W, Rapoport SI, and Rao JS*.Mol Psychiatry, April 2011;16(4):419–28.
7. Kim HW, Cheon Y, Modi HR, Rapoport SI, and Rao JS. Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in the rat brain. Psychopharmacology (Berl). 2012 Aug;222(4):663-74.

8. Cheon Y, Park JY, Modi HR, Kim HW, Lee HJ, Chang L, Rao JS, Rapoport SI. Chronic olanzapine treatment reduces arachidonic acid turnover and prostaglandin E2 concentrations in the rat brain, according to J Neurochem. 2011 Oct; 119(2):364-76.
9. Kim H-W, Rao JS, Rapoport SI, and Igarashi M. Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. Prostaglandins, Leukot Essent Fatty Acids. 2011 Dec;85(6):361-8.
10. Ramadhan E, Basselin M, Rao JS, Chang L, Chen M, Ma K, and Rapoport SI. Lamotrigine blocks NMDA receptor-initiated arachidonic acid signalling in the rat brain: implications for its efficacy in bipolar disorder. International Journal of Neuropsychopharmacology. 2011 Jun 28; 1-13.
11. Igarashi M, Kaizong Ma, Fei Gao, Kim H-W, Rapoport SI, and Rao JS. disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex. J Alzheimer's Dis. 2011;24(3):507-17.
12. In the rat brain, dietary n-6 PUFA deficiency reduces arachidonate metabolizing enzymes while increasing docosahexaenoate metabolizing enzymes.Biochim Biophys Acta 1811 (2): 111-7, February 2011.
13. Rao JS*, Jean Harry, Rapoport SI, and Kim HY are the authors.Increased excitotoxicity and neuroinflammatory markers in the postmortem frontal cortex of bipolar disorder patients. Mol. Psychiatry, April 2010; 15(4):384-92.
14. HJ Lee, JS Rao, L Chang, SI Rapoport, and HY KimChronic imipramine but not bupropion increases arachidonic acid signaling in the rat brain: is this related to "switching" in bipolar disorder? Mol Psychiatry, June 2010;15(6):602-14.
15. Kim, H-W, Rapoport, SI, and Rao, JS* Altered expression of apoptotic factors and synaptic markers in bipolar disorder patients' postmortem brains.Mar 2010;37(3):596-603.
16. Igarashi M, Ma K, Fei G, Kim H-W, Greenstein D, Rapoport SI, Rao JS. Brain lipid concentrations in bipolar disorder. Journal of Psychiatrist Research. 2010 Feb;44(3):177-82.
17. Kim H-W, Chang YC, Rapoport SI, and Rao JS*. Chronic NMDA administration to rats increases brain pro-apoptotic factors while decreasing anti-apoptotic factors and causes cell death. BMC Neurosci. Sep 28th, 2009; 10: 123.(Highly accessed article).
18. SI Rapoport, M Basselin, HY Kim, and JS Rao*.Bipolar disorder and the mechanisms of action of mood stabilizers Brain Res Rev., Oct 2009;61(2):185-209.
19. Rao JS, Lee H-J, Rapoport SI, and Bazinet RP. The mode of action of mood stabilizers: is the arachidonic acid cascade a common target? Mol Psychiatry, Jun 2008;13(6):585-96.
20. Lee HJ, Rao JS, Rapoport SI, Bazinet RP. Lessons learned about the regulation of fatty acid metabolism in the brain.Prostaglandins, Leukot Essent Fatty Acids. Nov-Dec 2007; 77(5-6): 239–46.
21. Lee HJ, Rao JS, Chang L, Rapoport SI, Bazinet RP. Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within the brain phospholipids of the unanesthetized rat. Jan 2008;49(1):162-8.
22. Rao, JS*, Ertley, RN, DeMar, JC, Jr., Rapoport, SI, Bazinet, RP, and Lee, HJ.Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in the rat frontal cortex. Molecular Psychiatry, February 2007;12(2):151-7.
23. Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder. Biol Psychiatry. 2006 Mar 1;59(5):401-7.
24. Bazinet RP, Rao JS, Chang L, Rapoport SI, Lee HJ. Chronic valproate does not alter the kinetics of docosahexaenoic acid within the brain phospholipids of the unanesthetized rat. Psychiatry (Berl). 2005 Oct;182(1):180-5.
25. Dwivedi Y, Rao JS, Rizavi HS, Kotowski J, Conley RR, Roberts RC, Pandey GN.Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in the postmortem brains of suicide subjects. Arch Gen Psychiatry, March 2003, 60(3): 273–82.
26. Pandey GN, Dwivedi Y, SridharaRao J, Ren X, Janicak PG, Sharma R. Inhibition of protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased, and expression of MARCKS is increased in the platelets of bipolar but not in unipolar patients. Neuropsychopharmacology, vol. 26, no. 2, pp. 216–28, 2002.
27. Subhash MN, Srinivas BN, Vinod KY, Jagadeesh S. In the rat brain, fluoxetine modifies the 5-HT1A receptor-mediated response.2000;107(3):377-87. J Neural Transm.
28. Dwivedi Y, Rizavi HS, Rao JS, Pandey GN. Modifications in the phosphoinositide signaling pathway by adrenal glucocorticoids in the rat brain: focus on phosphoinositide-specific phospholipase C and inositol 1,4,5-trisphosphate. J Exp Ther Pharmacol. 2000 Oct;295(1):244-54.
29. Subhash MN, Srinivas BN, Vinod KY, and Jagadeesh S. Inactivation of 5-HT1A and [3H] 5-HT binding sites by nethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) in the rat brain. Neurochem Res. Oct 1998;23(10):1321-6.
30. Antidepressants' effects on intracellular Ca++ mobilization in the human frontal cortex: Jagadeesh SR, Subhash MN. Antidepressants' effects on intracellular Ca++ mobilization in the human frontal cortex: Jagadeesh SR, Subhash MN.Biol Psychiatry, vol. 44, no. 7, p. 617-21, 1998.
31. Subhash MN, Jagadeesh S. Imipramine-induced changes in 5-HT2 receptor sites and inositoltrisphosphate levels in the rat brain. Sep 1997;22(9):1095-9.
32. The development of 3[H]-spiperone binding sites in the rat brainNIMHANS Journal, 1997, 15:167-175.
33. Lakshmana MK, Jagadeesh S, Subhash MN. Increased acetylcholinesterase activity in selected regions of the rat brain after chronic (-)-deprenyl administration Oct 1996;21(10):1209-12.
34. Gopumadhavan S, Jagadeesh S, Chauhan BL, Kulkarni RD. Protective effect of Liv.52 on alcohol-induced fetotoxicity. Alcohol Clin Exp Res. October 1993;17(5):1089–92.
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