Dario Renato Alessi, BSc, PhD
Affiliations: | 1988-1991 | School of Biochemistry | University of Birmingham, UK, Birmingham, England, United Kingdom |
| 1991- | College of Life Science | University of Dundee, Dundee, Scotland, United Kingdom |
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"Dario Alessi"Parents
Sign in to add mentor| Philip Cohen | grad student | (Chemistry Tree) | |
| Ian P. Trayer | grad student | 1988-1991 | University of Birmingham (UK) |
| David R. Trentham | grad student | 1988-1991 | University of Birmingham (UK) |
Children
Sign in to add trainee| Sourav Banerjee | grad student | (Chemistry Tree) | |
| José Ramón Bayascas | post-doc | (Evolution Tree) | |
| Laurie M. Gay | post-doc | (Cell Biology Tree) | |
| Jinwei Zhang | post-doc | 2011-2017 | University of Dundee |
Collaborators
Sign in to add collaborator| Kevin Michael O'Shaughnessy | collaborator | ||
| Keith Siew | collaborator | 2011-2016 | University of Dundee |
BETA: Related publications
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Publications
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| Zhu H, Tonelli F, Turk M, et al. (2023) Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science (New York, N.Y.). 382: 1404-1411 |
| Pal P, Taylor M, Lam PY, et al. (2023) Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B. Science Advances. 9: eadj1205 |
| Dhekne HS, Tonelli F, Yeshaw WM, et al. (2023) Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase. Elife. 12 |
| Arang N, Lubrano S, Ceribelli M, et al. (2023) High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma. Cell Reports. Medicine. 101244 |
| Hatcher JM, Zwirek M, Sarhan AR, et al. (2023) Development of a Highly Potent and Selective Degrader of LRRK2. Bioorganic & Medicinal Chemistry Letters. 129449 |
| Borsche M, Pratuseviciute N, Schaake S, et al. (2023) The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity. Movement Disorders : Official Journal of the Movement Disorder Society |
| Newton AC, Alessi DR. (2023) Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer. Iubmb Life. 75: 282-283 |
| Vides EG, Adhikari A, Chiang CY, et al. (2022) A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. Elife. 11 |
| Malik AU, Karapetsas A, Nirujogi RS, et al. (2022) PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. The Biochemical Journal. 479: 1941-1965 |
| Liu X, Kalogeropulou AF, Domingos S, et al. (2022) Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society |