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James E. Zadina

Affiliations: 
Tulane University, New Orleans, LA, United States 
Area:
peptides, endomorphins, pain, reward
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"James Zadina"
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Parents

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Arnold A. Gerall grad student 1977 Tulane Medical School
Abba J. Kastin post-doc 1977-1979 Tulane

Children

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Sheryl B. Martin-Schild grad student 1996-2000 Tulane
Marc A. Czapla grad student 2002 Tulane
Kristen A. Horner grad student 2002 Tulane
Tom N. Greenwell grad student 1998-2003 Tulane
Amy K. Feehan grad student 2014-2019 Tulane

Collaborators

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Roy Wise collaborator 2002- Tulane
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Publications

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Amgott-Kwan AT, Zadina JE. (2023) Endomorphin analog ZH853 shows low reward, tolerance, and affective-motivational signs of withdrawal, while inhibiting opioid withdrawal and seeking. Neuropharmacology. 227: 109439
Nilges MR, Laurent M, Cable C, et al. (2019) Discriminative Stimulus and Low Abuse Liability Effects of Novel Endomorphin Analogs Suggest a Potential Treatment Indication for Opioid Use Disorder. The Journal of Pharmacology and Experimental Therapeutics
Feehan AK, Zadina JE. (2019) Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization. Journal of Neuroinflammation. 16: 100
Feehan AK, Morgenweck J, Zhang X, et al. (2017) Novel Endomorphin Analogs are More Potent and Longer Lasting Analgesics in Neuropathic, Postoperative, Inflammatory, and Visceral Pain Relative to Morphine. The Journal of Pain : Official Journal of the American Pain Society
Zadina JE, Nilges MR, Morgenweck J, et al. (2015) Endomorphin Analog Analgesics with Reduced Abuse Liability, Respiratory Depression, Motor Impairment, Tolerance, and Glial Activation. Neuropharmacology
Nasirinezhad F, Gajavelli S, Priddy B, et al. (2015) Viral vectors encoding endomorphins and serine histogranin attenuate neuropathic pain symptoms after spinal cord injury in rats. Molecular Pain. 11: 2
Morgenweck J, Griggs RB, Donahue RR, et al. (2013) PPARγ activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. 70: 236-46
Chakrabarti S, Liu NJ, Zadina JE, et al. (2012) Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic. The Journal of Pharmacology and Experimental Therapeutics. 340: 56-63
Minokadeh A, Funkelstein L, Toneff T, et al. (2010) Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Molecular and Cellular Neurosciences. 43: 98-107
Greco MA, Fuller PM, Jhou TC, et al. (2008) Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus. Brain Research. 1245: 96-107
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