Jeremy J. Clemens, Ph.D.
Affiliations: | University of Virginia, Charlottesville, VA |
Area:
Bioorganic and Synthetic Organic ChemistryGoogle:
"Jeremy Clemens"Mean distance: 8.25 | S | N | B | C | P |
Parents
Sign in to add mentor| Timothy L. Macdonald | grad student | 2004 | UVA | |
| (Synthesis of subtype-selective sphingosine -1 -phosphate (S1P) receptor agonists and antagonists: Elucidation of a structure-activity relationship for S1P and the mechanism of action of FTY720.) | ||||
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Publications
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| Vilums M, Zweemer AJ, Barmare F, et al. (2015) When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. European Journal of Medicinal Chemistry. 93: 121-34 |
| Vilums M, Zweemer AJ, Yu Z, et al. (2013) Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists. Journal of Medicinal Chemistry. 56: 7706-14 |
| Foss FW, Clemens JJ, Davis MD, et al. (2005) Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15: 4470-4 |
| Clemens JJ, Davis MD, Lynch KR, et al. (2005) Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3568-72 |
| Bolick DT, Srinivasan S, Kim KW, et al. (2005) Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 976-81 |
| Davis MD, Clemens JJ, Macdonald TL, et al. (2005) Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemistry. 280: 9833-41 |
| Clemens JJ, Davis MD, Lynch KR, et al. (2004) Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 4903-6 |
| Clemens JJ, Davis MD, Lynch KR, et al. (2003) Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 13: 3401-4 |
| Im DS, Clemens J, Macdonald TL, et al. (2001) Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 40: 14053-60 |