Deborah M. Kurrasch-Orbaugh, Ph.D.

Purdue University, West Lafayette, IN, United States 
Dopamine and Serotonin Agonists
"Deborah Kurrasch-Orbaugh"
Mean distance: 18.16 (cluster 11)


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David E. Nichols grad student 2002 Purdue
 (Elucidation of the serotonin 5-HT(2A) receptor-coupled phospholipase A(2) signaling pathway.)
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Kurrasch-Orbaugh DM, Parrish JC, Watts VJ, et al. (2003) A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. Journal of Neurochemistry. 86: 980-91
Chambers JJ, Parrish JC, Jensen NH, et al. (2003) Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. Journal of Medicinal Chemistry. 46: 3526-35
Kurrasch-Orbaugh DM, Watts VJ, Barker EL, et al. (2003) Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. The Journal of Pharmacology and Experimental Therapeutics. 304: 229-37
Marona-Lewicka D, Kurrasch-Orbaugh DM, Selken JR, et al. (2002) Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats. Psychopharmacology. 164: 93-107
Nichols DE, Frescas S, Marona-Lewicka D, et al. (2002) Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD). Journal of Medicinal Chemistry. 45: 4344-9
Chambers JJ, Kurrasch-Orbaugh DM, Nichols DE. (2002) Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity. Bioorganic & Medicinal Chemistry Letters. 12: 1997-9
Chambers JJ, Kurrasch-Orbaugh DM, Parker MA, et al. (2001) Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. Journal of Medicinal Chemistry. 44: 1003-10
Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, et al. (1999) Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain. Journal of Medicinal Chemistry. 42: 4257-63
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