Benjamin R. Chemel, Ph.D.

Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Dopamine and Serotonin Agonists
"Benjamin Chemel"
Mean distance: 18.16 (cluster 11)


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David E. Nichols grad student 2010 Purdue
 (Exploring the molecular determinants of binding selectivity and efficacy for D1 dopamine receptor agonists.)
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Staffend NA, Hedges VL, Chemel BR, et al. (2014) Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience. Brain Structure & Function. 219: 2071-81
Chemel BR, Bonner LA, Watts VJ, et al. (2012) Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists. Molecular Pharmacology. 81: 729-38
Cueva JP, Chemel BR, Juncosa JI, et al. (2012) Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European Journal of Medicinal Chemistry. 48: 97-107
Bonner LA, Laban U, Chemel BR, et al. (2011) Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues. Chemmedchem. 6: 1024-40
Bonner LA, Chemel BR, Watts VJ, et al. (2010) Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorganic & Medicinal Chemistry. 18: 6763-70
Przybyla JA, Cueva JP, Chemel BR, et al. (2009) Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46
Marona-Lewicka D, Chemel BR, Nichols DE. (2009) Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology. 203: 265-77
Vidi PA, Chemel BR, Hu CD, et al. (2008) Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells. Molecular Pharmacology. 74: 544-51
Nichols DE, Frescas SP, Chemel BR, et al. (2008) High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand. Bioorganic & Medicinal Chemistry. 16: 6116-23
Cueva JP, Giorgioni G, Grubbs RA, et al. (2006) trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. Journal of Medicinal Chemistry. 49: 6848-57
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