Kristen J. Brennand, Ph.D.

2002-2007 Harvard University, Cambridge, MA, United States 
 2007-2012 Salk Institute for Biological Studies, La Jolla, CA, United States 
 2012-2020 Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Psychiatric genomics, human induced pluripotent stem cells, CRISPR
"Kristen Brennand"

My laboratory combines expertise in genetics, neuroscience and stem cells, in order to identify the mechanisms that underlie brain disease. Our focus lies in resolving the convergence of, and complex interplay between, the many risk variants linked to disease, towards the goal of facilitating the clinical translation of genetic findings.

Mean distance: 17.08 (cluster 18)
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Schrode N, Seah C, Deans PJM, et al. (2021) Analysis framework and experimental design for evaluating synergy-driving gene expression. Nature Protocols
Wang M, Li A, Sekiya M, et al. (2020) Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease. Neuron
Powell SK, O'Shea C, Brennand KJ, et al. (2020) Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological Psychiatry
Dobrindt K, Hoagland DA, Seah C, et al. (2020) Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology
Matos MR, Ho SM, Schrode N, et al. (2020) Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics. Molecular and Cellular Neurosciences. 103532
Powell SK, O'Shea CP, Shannon SR, et al. (2020) Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. Advances in Neurobiology. 25: 155-206
Gregory JA, Hoelzli E, Abdelaal R, et al. (2020) Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 9
Issler O, van der Zee YY, Ramakrishnan A, et al. (2020) Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression. Neuron
Sey NYA, Hu B, Mah W, et al. (2020) A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nature Neuroscience
Barretto N, Zhang H, Powell SK, et al. (2020) ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs. Journal of Neuroscience Methods. 334: 108548
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