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Henry Lee, Ph.D.

Affiliations: 
2010- Neurology Children's Hospital Boston, Harvard Medical School, Boston, MA, United States 
Area:
Brain plasticity, GABA, rare disease
Google:
"Hing Cheong Lee"
Bio:

I graduated from the Hong Kong University of Science and Technology in 2001 (BSc. in Biochemistry) and 2003 (MPhil. in Biology). My MPhil. supervisor was Prof. Karl W.K. Tsim. I moved to University of Pennsylvania in 2003 to start my PhD. study under the supervision of Prof. Stephen J. Moss. In 2008 I moved to Tufts University to continue my study with Prof. Moss and graduated in 2009. After working for a year as a post-doctoral associate with Prof. Moss I moved to Children's Hospital Boston, Harvard Medical School in 2010. I became a Senior Scientist, as well as the Preclinical Scientific Program Manager at the Rosamund Stone Zander Translational Neuroscience Center in 2021, working with Drs. Alexander Rotenberg and Mustafa Sahin. My main research interest includes a rare GABA catabolic disorder SSADH deficiency.

Mean distance: 13.84 (cluster 6)
 		SNBCP
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Parents

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Karl W. K. Tsim grad student 2001-2003 HKUST
Stephen J. Moss grad student 2003-2008 Penn
Stephen J. Moss post-doc 2009-2010 Tufts Medical School
Alexander Rotenberg post-doc 2013-2020 Harvard Medical School

Children

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Collaborators

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Rui Lin collaborator 2022-2023 Boston Children's Hospital
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Publications

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Tokatly Latzer I, Roullet JB, Afshar-Saber W, et al. (2024) Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder. Journal of Neurodevelopmental Disorders. 16: 21
Lee HHC, Latzer IT, Bertoldi M, et al. (2024) Gene replacement therapies for inherited disorders of neurotransmission: Current progress in succinic semialdehyde dehydrogenase deficiency. Journal of Inherited Metabolic Disease
Tokatly Latzer I, Bertoldi M, Blau N, et al. (2024) Consensus guidelines for the diagnosis and management of succinic semialdehyde dehydrogenase deficiency. Molecular Genetics and Metabolism. 142: 108363
Tokatly Latzer I, Yang E, Afacan O, et al. (2023) Glymphatic dysfunction coincides with lower GABA levels and sleep disturbances in succinic semialdehyde dehydrogenase deficiency. Journal of Sleep Research. e14105
Tokatly Latzer I, Roullet JB, Cesaro S, et al. (2023) Phenotypic correlates of structural and functional protein impairments resultant from ALDH5A1 variants. Human Genetics
Latzer IT, Roullet JB, Cesaro S, et al. (2023) Phenotypic Correlates of Structural and Functional Protein Impairments Resultant from ALDH5A1 Variants. Research Square
Tokatly Latzer I, Bertoldi M, DiBacco ML, et al. (2023) The Presence and Severity of Epilepsy Coincide with Reduced GABA and Cortical Excitatory Markers in SSADH Deficiency. Epilepsia
Pearl PL, Tokatly-Latzer I, Lee HH, et al. (2023) New Therapeutic Approaches to Inherited Metabolic Pediatric Epilepsies. Neurology
Hameed MQ, Hodgson N, Lee HHC, et al. (2022) N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model. Cerebral Cortex (New York, N.Y. : 1991)
Lee HHC, McGinty GE, Pearl PL, et al. (2022) Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted Medicine. International Journal of Molecular Sciences. 23
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