Alexander R. McCampbell, Ph.D.
Institution:
University of Pennsylvania, Philadelphia, PA, United StatesGoogle:
"Alexander McCampbell"Mean distance: 18.31 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| Kenneth H. Fischbeck | grad student | 2001 | Penn | |
| (Transcriptional co -activator dysfunction in polyglutamine disease.) | ||||
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Publications
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| Cook CN, Wu Y, Odeh HM, et al. (2020) poly(GR) aggregation induces TDP-43 proteinopathy. Science Translational Medicine. 12 |
| Zhang YJ, Guo L, Gonzales PK, et al. (2019) Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363 |
| Sweeney P, Park H, Baumann M, et al. (2017) Protein misfolding in neurodegenerative diseases: implications and strategies. Translational Neurodegeneration. 6: 6 |
| Periz G, Lu J, Zhang T, et al. (2015) Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription. Plos Biology. 13: e1002114 |
| Ma L, Seager MA, Seager M, et al. (2009) Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proceedings of the National Academy of Sciences of the United States of America. 106: 15950-5 |
| McCampbell A, Taye AA, Whitty L, et al. (2001) Histone deacetylase inhibitors reduce polyglutamine toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 15179-84 |
| Steffan JS, Bodai L, Pallos J, et al. (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 413: 739-43 |
| McCampbell A, Fischbeck KH. (2001) Polyglutamine and CBP: fatal attraction? Nature Medicine. 7: 528-30 |
| McCampbell A, Taylor JP, Taye AA, et al. (2000) CREB-binding protein sequestration by expanded polyglutamine. Human Molecular Genetics. 9: 2197-202 |