Joseph W. Lewcock, Ph.D.

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Olfaction
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"Joseph Lewcock"
Mean distance: 17.65 (cluster 11)
 
SNBCP

Parents

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Randall R. Reed grad student 2004 Johns Hopkins
 (Molecular mechanisms regulating mono -allelic odorant receptor expression.)

Children

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Gregory B. Potter research scientist 2016-2018
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Publications

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Nugent AA, Lin K, van Lengerich B, et al. (2019) TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron
Fang MY, Markmiller S, Vu AQ, et al. (2019) Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron
Naguib A, Sandmann T, Yi F, et al. (2019) SUPT4H1 Depletion Leads to a Global Reduction in RNA. Cell Reports. 26: 45-53.e4
Patel S, Harris SF, Gibbons P, et al. (2015) Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). Journal of Medicinal Chemistry
Rudhard Y, Sengupta Ghosh A, Lippert B, et al. (2015) Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2927-41
Patel S, Cohen F, Dean BJ, et al. (2015) Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. Journal of Medicinal Chemistry. 58: 401-18
Lobsiger CS, Boillée S, Pozniak C, et al. (2013) C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proceedings of the National Academy of Sciences of the United States of America. 110: E4385-92
Pozniak CD, Sengupta Ghosh A, Gogineni A, et al. (2013) Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. The Journal of Experimental Medicine. 210: 2553-67
Huntwork-Rodriguez S, Wang B, Watkins T, et al. (2013) JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. The Journal of Cell Biology. 202: 747-63
Watkins TA, Wang B, Huntwork-Rodriguez S, et al. (2013) DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 110: 4039-44
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