Sokhom S. Pin, Ph.D.

Affiliations: 
University of Connecticut, Storrs, CT, United States 
Area:
Neuroprotection in models of Alzheimer-type pathogenesis
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"Sokhom Pin"
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Parents

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Ben A. Bahr grad student 2007 University of Connecticut
 (Functional desensitization of calcitonin gene -related peptide (CGRP) receptors in SK -N -MC cells.)
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Publications

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Tora G, Degnan AP, Conway CM, et al. (2013) Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 5684-8
Chaturvedula PV, Mercer SE, Pin SS, et al. (2013) Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery. Bioorganic & Medicinal Chemistry Letters. 23: 3157-61
Han X, Civiello RL, Conway CM, et al. (2013) The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2. Bioorganic & Medicinal Chemistry Letters. 23: 1870-3
Han X, Civiello RL, Conway CM, et al. (2012) The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1. Bioorganic & Medicinal Chemistry Letters. 22: 4723-7
Luo G, Chen L, Pin SS, et al. (2012) Calcitonin gene-related peptide (CGRP) receptor antagonists: novel aspartates and succinates. Bioorganic & Medicinal Chemistry Letters. 22: 2912-6
Luo G, Chen L, Civiello R, et al. (2012) Calcitonin gene-related peptide (CGRP) receptor antagonists: pyridine as a replacement for a core amide group. Bioorganic & Medicinal Chemistry Letters. 22: 2917-21
Vrudhula VM, Dasgupta B, Pin SS, et al. (2010) Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R). Bioorganic & Medicinal Chemistry Letters. 20: 1905-9
Degnan AP, Chaturvedula PV, Conway CM, et al. (2008) Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. Journal of Medicinal Chemistry. 51: 4858-61
Pin SS, Bahr BA. (2008) Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists. European Journal of Pharmacology. 587: 8-15
Pin SS, Xu C, Bahr BA. (2007) Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. European Journal of Pharmacology. 577: 7-16
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