Andrea J. Mothe, Ph.D.

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Biomedical Engineering
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"Andrea Mothe"
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Ian Brown grad student 2002 University of Toronto
 (Expression of mRNA encoding the related extracellular matrix glycoproteins, SC1 and SPARC, in the developing and adult rat central nervous system.)
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Publications

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Hachem LD, Hong J, Velumian A, et al. (2023) Excitotoxic glutamate levels drive spinal cord ependymal stem cell proliferation and fate specification through CP-AMPAR signaling. Stem Cell Reports
Mothe AJ, Jacobson PB, Caprelli M, et al. (2022) Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury. Neurobiology of Disease. 105812
Jacobson PB, Goody R, Lawrence M, et al. (2021) Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemi-compression spinal cord injury in non-human primates. Neurobiology of Disease. 105385
Ahuja CS, Mothe A, Khazaei M, et al. (2020) The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem Cells Translational Medicine
Mothe AJ, Coelho M, Huang L, et al. (2020) Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats. Neurobiology of Disease. 104995
Hachem LD, Mothe AJ, Tator CH. (2019) Unlocking the Paradoxical Endogenous Stem Cell Response after Spinal Cord Injury. Stem Cells (Dayton, Ohio)
Caprelli MT, Mothe AJ, Tator C. (2018) Hyperphosphorylated tau as a novel biomarker for traumatic axonal injury in the spinal cord. Journal of Neurotrauma
Caprelli MT, Mothe AJ, Tator CH. (2017) CNS Injury: Posttranslational Modification of the Tau Protein as a Biomarker. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858417742125
Hachem LD, Mothe AJ, Tator CH. (2017) Positive Modulation of AMPA Receptors Promotes Survival and Proliferation of Neural Stem/Progenitor Cells from the Adult Rat Spinal Cord. Stem Cells and Development
Mothe AJ, Tassew NG, Shabanzadeh AP, et al. (2017) RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury. Scientific Reports. 7: 10529
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