William R. Marrs, Ph.D.

University of Washington, Seattle, Seattle, WA
Cannabinoid signaling and neuroinflammation
"William Marrs"
Mean distance: 15.48 (cluster 6)


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Nephi Stella grad student 2011 University of Washington
 (The Serine Hydrolase ABHD6 Regulates Endocannabinoid Signaling.)
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Naydenov AV, Horne EA, Cheah CS, et al. (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 83: 361-71
Horne EA, Coy J, Swinney K, et al. (2013) Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models. The European Journal of Neuroscience. 37: 429-40
Marrs WR, Horne EA, Ortega-Gutierrez S, et al. (2011) Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. The Journal of Biological Chemistry. 286: 28723-8
Marrs WR, Blankman JL, Horne EA, et al. (2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nature Neuroscience. 13: 951-7
Cudaback E, Marrs W, Moeller T, et al. (2010) The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas. Plos One. 5: e8702
Marrs W, Stella N. (2009) Measuring endocannabinoid hydrolysis: refining our tools and understanding. The Aaps Journal. 11: 307-11
Marrs W, Stella N. (2007) 2-AG + 2 new players = forecast for therapeutic advances. Chemistry & Biology. 14: 1309-11
Marrs W, Kuperman J, Avedian T, et al. (2005) Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1500-10
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