Luca Posa, Pharm.D., Ph.D.

Affiliations: 
2010-2014 Pharmacology Università di Bologna, Bologna, Italy 
 2012-2013 CNRS & Université Paris Descartes 
 2014-2015 Pharmacology CHU Ste. Justine, Universite de Montreal, Montréal, Québec, Canada 
 2015- Psychiatry McGill University, Montreal, QC, Canada 
Area:
opioid, melatonin, pain, tolerance
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Publications

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Boccella S, Fusco A, Ricciardi F, et al. (2024) Acute Kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats. Neuropharmacology. 110265
López-Canul M, He Q, Sasson T, et al. (2024) Selective Enhancement of REM Sleep in Male Rats through Activation of MT Receptors Located in the Locus Coeruleus Norepinephrine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Pearl-Dowler L, Posa L, Lopez-Canul M, et al. (2023) Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 110805
Gamble MC, Williams BR, Singh N, et al. (2022) Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and reward. Frontiers in Systems Neuroscience. 16: 1059089
Rullo L, Caputi FF, Losapio LM, et al. (2022) Effects of Different Opioid Drugs on Oxidative Status and Proteasome Activity in SH-SY5Y Cells. Molecules (Basel, Switzerland). 27
Posa L, De Gregorio D, He Q, et al. (2022) Supraspinal melatonin MT receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors. Journal of Pineal Research
Rullo L, Posa L, Caputi FF, et al. (2021) Nociceptive behavior and central neuropeptidergic dysregulations in male and female mice of a Fabry disease animal model. Brain Research Bulletin. 175: 158-167
De Gregorio D, Popic J, Enns JP, et al. (2021) Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America. 118
Caputi FF, Di Cesare Mannelli L, Rullo L, et al. (2020) The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms. Biochemical Pharmacology. 182: 114255
De Gregorio D, Dean Conway J, Canul ML, et al. (2020) Effects of chronic exposure to low doses of Δ9- tetrahydrocannabinol in adolescence and adulthood on serotonin/norepinephrine neurotransmission and emotional behaviors. The International Journal of Neuropsychopharmacology
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