Lalitha Madhavan, Ph.D.

Affiliations: 
Iowa State University, Ames, IA, United States 
Area:
Stem cells, neuroregeneration
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"Lalitha Madhavan"
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Vaclav Ourednik grad student 2006 Iowa State
 (Dynamics of neural stem cell-mediated neuroprotection in the presence of oxidative stress: Studies in vitro and in vivo.)
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Publications

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Madhavan L, Daley BF, Davidson BL, et al. (2015) Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. Plos One. 10: e0137136
Corenblum MJ, Flores AJ, Badowski M, et al. (2015) Systemic human CD34(+) cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration. Regenerative Medicine. 10: 563-77
Paumier KL, Sortwell CE, Madhavan L, et al. (2015) Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system. Experimental Neurology. 266: 11-21
Paumier KL, Sortwell CE, Madhavan L, et al. (2015) Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 874-83
Madhavan L. (2015) Redox-based regulation of neural stem cell function and Nrf2 Biochemical Society Transactions. 43: 627-631
Paumier KL, Siderowf AD, Auinger P, et al. (2012) Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 880-7
Madhavan L, Daley BF, Sortwell CE, et al. (2012) Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat. The European Journal of Neuroscience. 35: 883-95
Gombash SE, Lipton JW, Collier TJ, et al. (2012) Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 544-54
Kordower JH, Dodiya HB, Kordower AM, et al. (2011) Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat. Neurobiology of Disease. 43: 552-7
Spieles-Engemann AL, Behbehani MM, Collier TJ, et al. (2010) Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiology of Disease. 39: 105-15
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