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Katherine S. Damme

Northwestern University, Evanston, IL 
Corticostriatal Connectivity, MRI, DTI, Reward, Bipolar Disorder, Schizophrenia, TMS, EEG, Hormones, Neuroimmunology
"Katherine Damme"

My research integrates neuroimaging techniques to identifying the neural underpinnings of risk taking, reward and motivation. The cortico-striatal network is particularly interesting because of it's transdiagnostic associations, from depression to mania. It even has implications for treatment of other disorders like schizophrenia and drug addiction.

Cortico-striatal network dysregulation underlies some of society’s most costly social problems, including drug use, impulsivity, and risk taking behaviors. My research models both structural (how regions physically connect) and functional (how regions communicate) connectivity in the cortico-striatal network to predicts clinical symptoms and risk for psychopathology. My research also investigates mechanisms by which neuroendocrine and neuroimmunological modulate functional and structural connectivity between cortico-striatal. Finally, I am investigating the manipulations of these network relationships with TMS and tDCS.

Mean distance: 20.62 (cluster 29)


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David H. Zald research assistant 2007-2011 Vanderbilt
Karen F. Berman research assistant 2011-2013 National Institutes of Health
 (Section on Integrative Neuroimaging IRTA Fellow)
Robin Nusslock grad student 2013- Northwesterb University (PsychTree)
 (Brain, Behavior, and Cognition)


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Lauren B. Alloy collaborator 2013- Temple University
Susan Bookheimer collaborator 2014-
 (BrainMAPD Project: Brain, Motivation, and Personality Development)
Michelle G. Craske collaborator 2014-
 (BrainMAPD Project: Brain, Motivation, and Personality Development)
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Damme KSF, Alloy LB, Young CB, et al. (2020) Amygdala subnuclei volume in bipolar spectrum disorders: Insights from diffusion-based subsegmentation and a high-risk design. Human Brain Mapping
Langenecker SA, Kling LR, Crane NA, et al. (2019) Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration. Drug and Alcohol Dependence. 107725
Damme KSF, Gupta T, Nusslock R, et al. (2019) Cortical Morphometry in the Psychosis Risk Period: A Comprehensive Perspective of Surface Features. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 4: 434-443
Vargas T, Maloney J, Gupta T, et al. (2019) Measuring facets of reward sensitivity, inhibition, and impulse control in individuals with problematic Internet use. Psychiatry Research. 275: 351-358
Damme KSF, Kelley NJ, Quinn ME, et al. (2019) Emotional content impacts how executive function ability relates to willingness to wait and to work for reward. Cognitive, Affective & Behavioral Neuroscience
Damme KS, Young CB, Nusslock R. (2017) Elevated nucleus accumbens structural connectivity associated with proneness to hypomania: a reward hypersensitivity perspective. Social Cognitive and Affective Neuroscience
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