Michael D. Diem, Ph.D.

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Spinal Muscular Atrophy, RNA binding proteins, Splicing, High-Throughput Screening
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"Michael Diem"
Mean distance: 17.41 (cluster 11)
 
SNBCP

Parents

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Gideon Dreyfuss grad student 2006 Penn
 (Protein interactions among the components of the exon junction complex.)
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Publications

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Diem MD, Hyun L, Yi F, et al. (2014) Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions. Protein Engineering, Design & Selection : Peds. 27: 419-29
Berg MG, Wan L, Younis I, et al. (2012) A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Molecular and Cellular Biology. 32: 1271-83
Jacobs SA, Diem MD, Luo J, et al. (2012) Design of novel FN3 domains with high stability by a consensus sequence approach. Protein Engineering, Design & Selection : Peds. 25: 107-17
Kataoka N, Diem MD, Yoshida M, et al. (2011) Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA. Scientific Reports. 1: 92
Diem MD, Chan CC, Younis I, et al. (2007) PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Nature Structural & Molecular Biology. 14: 1173-9
Chan CC, Dostie J, Diem MD, et al. (2004) eIF4A3 is a novel component of the exon junction complex. Rna (New York, N.Y.). 10: 200-9
Lau CK, Diem MD, Dreyfuss G, et al. (2003) Structure of the Y14-Magoh core of the exon junction complex. Current Biology : Cb. 13: 933-41
Kataoka N, Diem MD, Kim VN, et al. (2001) Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. The Embo Journal. 20: 6424-33
Kim VN, Yong J, Kataoka N, et al. (2001) The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. The Embo Journal. 20: 2062-8
Patick AK, Binford SL, Brothers MA, et al. (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrobial Agents and Chemotherapy. 43: 2444-50
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