Saak V. Ovsepian, Ph.D., M.D.

Neuroscience Dublin City University, ICNT 
Ion channels, Synaptic Transmission, Neurodegenerative Disorders
"Saak Ovsepian"
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Willem M, Tahirovic S, Busche MA, et al. (2015) η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature
Filser S, Ovsepian SV, Masana M, et al. (2015) Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. Biological Psychiatry. 77: 729-39
Ochs SM, Dorostkar MM, Aramuni G, et al. (2015) Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin. Molecular Psychiatry. 20: 482-9
Ovsepian SV, O'Leary VB. (2015) Neuronal Activity and Amyloid Plaque Pathology: An Update Journal of Alzheimer's Disease. 49: 13-19
O'Leary V, Ovsepian SV, Carrascosa LG, et al. (2015) PARTICLE, a triplex-forming long ncRNA, regulates locus-specific methylation in response to low-dose irradiation Cell Reports. 11: 474-485
Ovsepian SV, Elekes K. (2015) From network architecture of forebrain systems to brain wide web Basal Ganglia. 5: 11-14
Ovsepian SV, Vesselkin NP. (2014) Wiring prior to firing: the evolutionary rise of electrical and chemical modes of synaptic transmission. Reviews in the Neurosciences. 25: 821-32
Bagchi B, Al-Sabi A, Kaza S, et al. (2014) Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination. Plos One. 9: e87736
Ovsepian SV, Antyborzec I, O'Leary VB, et al. (2014) Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Brain Structure & Function. 219: 1527-41
Neuner J, Ovsepian SV, Dorostkar M, et al. (2014) Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb Nature Communications. 5
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