Prafulla Aryal, Ph.D.

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
GIRK channels, addiction, plasticity, G proteins
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"Prafulla Aryal"
Mean distance: 15.26 (cluster 6)
 
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Parents

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Paul A. Slesinger grad student 2010 UCSD
 (Insights into mechanism of alcohol mediated modulation of GIRK channels.)
Diana Bautista post-doc 2010-2012 UC Berkeley
Mark S.P. Sansom post-doc 2012-2016 Oxford
Stephen J. Tucker post-doc 2012-2016 Oxford
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Publications

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Nematian-Ardestani E, Jarerattanachat V, Aryal P, et al. (2017) The Effects of Stretch Activation on Ionic Selectivity of the TREK-2 K2P K(+) Channel. Channels (Austin, Tex.). 0
Lacin E, Aryal P, Glaaser IW, et al. (2017) Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel. The Journal of General Physiology
Aryal P, Jarerattanachat V, Clausen MV, et al. (2017) Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure (London, England : 1993)
Trick JL, Chelvaniththilan S, Klesse G, et al. (2016) Functional Annotation of Ion Channel Structures by Molecular Simulation. Structure (London, England : 1993)
McClenaghan C, Schewe M, Aryal P, et al. (2016) Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. The Journal of General Physiology. 147: 497-505
Trick JL, Aryal P, Tucker SJ, et al. (2015) Molecular simulation studies of hydrophobic gating in nanopores and ion channels. Biochemical Society Transactions. 43: 146-50
Dong YY, Pike AC, Mackenzie A, et al. (2015) K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science (New York, N.Y.). 347: 1256-9
Aryal P, Abd-Wahab F, Bucci G, et al. (2015) Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel. Channels (Austin, Tex.). 9: 44-9
Aryal P, Sansom MS, Tucker SJ. (2015) Hydrophobic gating in ion channels. Journal of Molecular Biology. 427: 121-30
Aryal P, Abd-Wahab F, Bucci G, et al. (2014) A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. Nature Communications. 5: 4377
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