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Anna E. Speers, Ph.D.

Affiliations: 
2005 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Medicinal Chemistry
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"Anna Speers"
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Parents

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Morgan Conn research assistant 1999-2000 Amherst College (Chemistry Tree)
Benjamin F. Cravatt grad student 2005 Scripps Institute
 (Advanced click chemistry strategies for in vivo enzyme activity profiling.)

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Publications

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Chang JW, Zuhl AM, Speers AE, et al. (2015) Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32
Zhao N, Darby CM, Small J, et al. (2015) Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71
Ward J, Spath SN, Pabst B, et al. (2013) Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling. Biochemistry. 52: 9187-201
Hsu KL, Tsuboi K, Chang JW, et al. (2013) Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry. 56: 8270-9
Hsu KL, Tsuboi K, Whitby LR, et al. (2013) Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Journal of Medicinal Chemistry. 56: 8257-69
Nagano JM, Hsu KL, Whitby LR, et al. (2013) Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43
Liu X, Dix M, Speers AE, et al. (2012) Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9. Chembiochem : a European Journal of Chemical Biology. 13: 2082-93
Saario SM, McKinney MK, Speers AE, et al. (2012) Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). Chemical Science (Royal Society of Chemistry : 2010). 3: 77-83
Adibekian A, Martin BR, Chang JW, et al. (2012) Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8
Rowland MM, Bostic HE, Gong D, et al. (2011) Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners. Biochemistry. 50: 11143-61
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