Ayano Sakai, Ph.D.

Affiliations: 
2009 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
structure/function relationships for enzyme-catalyzed reactions
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"Ayano Sakai"
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Parents

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John A. Gerlt grad student 2009 UIUC
 (Study of enzyme evolution within the MLE subgroup focusing on characterizing member enzymes for the purpose of discovering relationships among sequence, structure, and function.)
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Publications

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Zhao S, Sakai A, Zhang X, et al. (2014) Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks. Elife. 3
Odokonyero D, Sakai A, Patskovsky Y, et al. (2014) Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family. Proceedings of the National Academy of Sciences of the United States of America. 111: 8535-40
Kumar R, Zhao S, Vetting MW, et al. (2014) Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine. Mbio. 5: e00933-13
Zhao S, Sakai A, Zhang X, et al. (2014) Author response: Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks Elife
Zhao S, Kumar R, Sakai A, et al. (2013) Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature. 502: 698-702
Lukk T, Sakai A, Kalyanaraman C, et al. (2012) Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 109: 4122-7
Sakai A, Fedorov AA, Fedorov EV, et al. (2009) Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes. Biochemistry. 48: 1445-53
Sakai A, Fedorov AA, Fedorov EV, et al. (2009) Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families ofcis,cis-Muconate Lactonizing Enzymes Biochemistry. 48: 2569-2570
Glasner ME, Fayazmanesh N, Chiang RA, et al. (2006) Evolution of Structure and Function in the o-Succinylbenzoate Synthase/N-Acylamino Acid Racemase Family of the Enolase Superfamily Journal of Molecular Biology. 360: 228-250
Sakai A, Xiang DF, Xu C, et al. (2006) Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids. Biochemistry. 45: 4455-62
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