Sean O'Leary, Ph.D.

Affiliations: 
2010 Cornell University, Ithaca, NY, United States 
Area:
Barton Professor of Chemistry
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"Sean O'Leary"
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Tadhg P. Begley grad student 2010 Cornell
 (Exploring novel enzymology in bacterial metabolism: Cysteine synthase, urate oxidase, and bacimethrin biosynthesis.)
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Publications

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Cooper LE, O'Leary SE, Begley TP. (2014) Biosynthesis of a thiamin antivitamin in Clostridium botulinum. Biochemistry. 53: 2215-7
Gokulan K, O'Leary SE, Russell WK, et al. (2013) Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. The Journal of Biological Chemistry. 288: 16484-94
Hicks KA, O'Leary SE, Begley TP, et al. (2013) Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae. Biochemistry. 52: 477-87
Paul D, O'Leary SE, Rajashankar K, et al. (2010) Glycal formation in crystals of uridine phosphorylase. Biochemistry. 49: 3499-509
O'Leary SE, Hicks KA, Ealick SE, et al. (2009) Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. Biochemistry. 48: 3033-5
O'Leary SE, Jurgenson CT, Ealick SE, et al. (2008) O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. Biochemistry. 47: 11606-15
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