Anton I. Rosenbaum, Ph.D.
Affiliations: | 2011 | Weill Cornell Medical College, New York, NY, United States |
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"Anton Rosenbaum"Mean distance: 18.02 (cluster 32) | S | N | B | C | P |
Parents
Sign in to add mentor| Frederick R. Maxfield | grad student | 2011 | Weill Cornell Medical College | |
| (Potential therapeutics for lysosomal storage disorders: Chemical biology dissection of cholesterol homeostasis mechanisms in mammalian cells.) | ||||
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| Ruff CT, Koren MJ, Grimsby J, et al. (2021) LEGACY: Phase 2a Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamic Effects of the Anti-EL (Endothelial Lipase) Antibody MEDI5884 in Patients With Stable Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120315757 |
| Le Lay JE, Du Q, Mehta MB, et al. (2021) Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial. Science Translational Medicine. 13 |
| Rosenbaum AI, Maxfield FR. (2011) Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches. Journal of Neurochemistry. 116: 789-95 |
| Rosenbaum AI, Cosner CC, Mariani CJ, et al. (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 53: 5281-9 |
| Rosenbaum AI, Zhang G, Warren JD, et al. (2010) Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 5477-82 |
| Cosner CC, Markiewicz JT, Bourbon P, et al. (2009) Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 52: 6494-8 |
| Rosenbaum AI, Rujoi M, Huang AY, et al. (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochimica Et Biophysica Acta. 1791: 1155-65 |