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Amy C. Seila, Ph.D.

Affiliations: 
2004 Yale University, New Haven, CT 
Area:
RNA, Ribosome
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"Amy Seila"
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Parents

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Scott A. Strobel grad student 2004 Yale
 (Determining the mechanism of peptidyl transferase in the 50S ribosomal subunit.)
Phillip Allen Sharp post-doc MIT

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Publications

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Rahl PB, Lin CY, Seila AC, et al. (2010) c-Myc regulates transcriptional pause release. Cell. 141: 432-45
Seila AC, Core LJ, Lis JT, et al. (2009) Divergent transcription: a new feature of active promoters. Cell Cycle (Georgetown, Tex.). 8: 2557-64
Seila AC, Calabrese JM, Levine SS, et al. (2008) Divergent transcription from active promoters. Science (New York, N.Y.). 322: 1849-51
Seila AC, Sharp PA. (2008) Small RNAs tell big stories in Whistler. Nature Cell Biology. 10: 630-3
Calabrese JM, Seila AC, Yeo GW, et al. (2007) RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 18097-102
Calabrese JM, Seila AC, Yeo GW, et al. (2007) RNA sequence analysis defines Dicer's role in mouse embryonic stem cells (Proceedings of the National Academy of Science of the United States of America (November 13, 2007) 104, 46, (18097-18102) DOI: 10.1073/pnas.0709193104) Proceedings of the National Academy of Sciences of the United States of America. 104: 21021
Okuda K, Seila AC, Strobel SA. (2005) Uncovering the enzymatic pKa of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative. Biochemistry. 44: 6675-84
Seila AC, Okuda K, Núñez S, et al. (2005) Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction. Biochemistry. 44: 4018-27
Okuda K, Seila AC, Strobel SA. (2004) Synthesis of isotopically labeled puromycin derivatives for kinetic isotope effect analysis of ribosome catalyzed peptide bond formation Tetrahedron. 60: 12101-12112
Parnell KM, Seila AC, Strobel SA. (2002) Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center. Proceedings of the National Academy of Sciences of the United States of America. 99: 11658-63
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