Qian Xie, Ph.D.
Affiliations: | 2014 | Biochemistry, Biophysics, and Molecular Biology | Iowa State University, Ames, IA, United States |
Area:
Nuclear magnetic resonance, Macromolecular structure and recognitionGoogle:
"Qian Xie"Mean distance: 8.15 | S | N | B | C | P |
Parents
Sign in to add mentor| Amy H. Andreotti | grad student | 2014 | Iowa State | |
| (Mechanistic insight into the regulation of Tec family kinase activity -- substrate selection and conformational preferences.) | ||||
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Publications
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| Xie Q, Wiedmann MM, Zhao A, et al. (2020) Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC. Chemical Communications (Cambridge, England) |
| Xie Q, Zhao A, Jeffrey PD, et al. (2019) Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chemical Biology |
| Wang B, Zhao A, Xie Q, et al. (2017) Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chemical Biology. 24: 76-86 |
| Xie Q, Fulton DB, Andreotti AH. (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. Acs Chemical Biology. 10: 262-8 |
| Boyken SE, Chopra N, Xie Q, et al. (2014) A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. Journal of Molecular Biology. 426: 3656-69 |
| Joseph RE, Kleino I, Wales TE, et al. (2013) Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Science Signaling. 6: ra76 |
| Xie Q, Joseph RE, Fulton DB, et al. (2013) Substrate recognition of PLCγ1 via a specific docking surface on Itk. Journal of Molecular Biology. 425: 683-96 |
| Joseph RE, Xie Q, Andreotti AH. (2010) Identification of an allosteric signaling network within Tec family kinases. Journal of Molecular Biology. 403: 231-42 |
| Shen Y, Xie Q, Norberg M, et al. (2005) Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation. Bioorganic & Medicinal Chemistry. 13: 4960-71 |