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Daniel W. Kulp, Ph.D.

Affiliations: 
2010 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Organic Chemistry, Chemical Biology, De Novo Protein Design
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William F. DeGrado grad student 2010 Penn
 (Using structural bioinformatics to model and design membrane proteins.)

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Publications

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Moyer TJ, Kato Y, Abraham W, et al. (2020) Engineered immunogen binding to alum adjuvant enhances humoral immunity. Nature Medicine
Steichen JM, Lin YC, Havenar-Daughton C, et al. (2019) A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science (New York, N.Y.)
Tokatlian T, Read BJ, Jones CA, et al. (2018) Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science (New York, N.Y.)
Kulp DW, Steichen JM, Pauthner M, et al. (2017) Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding. Nature Communications. 8: 1655
Cao L, Diedrich JK, Kulp DW, et al. (2017) Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. Nature Communications. 8: 14954
Crooks ET, Osawa K, Tong T, et al. (2017) Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction. Virology. 505: 193-209
Steichen JM, Kulp DW, Tokatlian T, et al. (2016) HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity
Briney B, Sok D, Jardine JG, et al. (2016) Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell. 166: 1459-1470.e11
Pritchard LK, Spencer DI, Royle L, et al. (2015) Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies. Nature Communications. 6: 7479
Jardine JG, Ota T, Sok D, et al. (2015) Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen. Science (New York, N.Y.)
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