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Joanne Cleary, Ph.D.

Affiliations: 
2002 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
anti-DNA autoantibody structure and function, and the identification of novel molecular targets and small molecules for the treatment of autoimmune diseases and cancer
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"Joanne Cleary"
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Gary D. Glick grad student 2002 University of Michigan
 (Role of binding site residues in the sequence -specific recognition of ssDNA by an autoantibody.)

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Publications

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Stelzer AC, Frazee RW, Van Huis C, et al. (2010) NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. Biopolymers. 93: 85-92
Bobeck MJ, Cleary J, Beckingham JA, et al. (2007) Effect of somatic mutation on DNA binding properties of anti-DNA autoantibodies. Biopolymers. 85: 471-80
Cleary J, Johnson KM, Opipari AW, et al. (2007) Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor. Bioorganic & Medicinal Chemistry Letters. 17: 1667-70
Johnson KM, Cleary J, Fierke CA, et al. (2006) Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase. Acs Chemical Biology. 1: 304-8
Francis TM, Sundberg TB, Cleary J, et al. (2006) Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones. Bioorganic & Medicinal Chemistry Letters. 16: 2423-7
Cleary J, Sitwala KV, Khodadoust MS, et al. (2005) p300/CBP-associated factor drives DEK into interchromatin granule clusters. The Journal of Biological Chemistry. 280: 31760-7
Adams BS, Cha HC, Cleary J, et al. (2003) DEK binding to class II MHC Y-box sequences is gene- and allele-specific. Arthritis Research & Therapy. 5: R226-33
Beckingham JA, Cleary J, Bobeck M, et al. (2003) Kinetic analysis of sequence-specific recognition of ssDNA by an autoantibody. Biochemistry. 42: 4118-26
Cleary J, Glick GD. (2003) Mutational analysis of a sequence-specific ssDNA binding lupus autoantibody. Biochemistry. 42: 30-41
Ackroyd PC, Cleary J, Glick GD. (2001) Thermodynamic basis for sequence-specific recognition of ssDNA by an autoantibody. Biochemistry. 40: 2911-22
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