Stevan N. Djakovic, PhD

Affiliations: 
2017- Clinical Science Genentech, San Francisco, CA, United States 
Area:
Autophagy, Ubiquitin Proteasome System, Neurodegenerative Disease, oncology
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"Stevan Djakovic"
Bio:

Stevan Djakovic works as a clinical scientist supporting the development of venetoclax for treatment of CLL, at Roche/Genentech.
Previously he was at Cleave Biosciences where he started working in 2012 as an Associate Scientist responsible for the identification and characterization of novel small molecule inhibitors of protein homeostasis for solid tumor and hematological cancers. Following identification of the lead Candidate inhibitor to p97 he transitioned into a new role in the clinical department where he was the lead clinical scientist on three phase 1/2 clinical trials. Additionally he was responsible for developing the clinical pharmacodynamic and patient enrichment biomarker assays. Prior to joining Cleave he was a contract Senior Research Associate at Genentech with Avi Ashkenazi where he was involved in discovery and characterization of novel dual specificity FGFR antibody therapeutics. Stevan received his BS and PhD in Biology from UCSD and also received postdoctoral training at the UCSD School of Medicine. In his free time he can be found backpacking, running or cycling with his wife.
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Mean distance: 16.1 (cluster 11)
 
SNBCP

Parents

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Laurie G. Smith research assistant 2001-2004 UCSD (Plant Biology Tree)
Gentry N. Patrick grad student 2004-2010 UCSD
 (Dynamic regulation of proteasome function by neuronal activity.)
Al La Spada post-doc 2010-2011 UCSD
Avi Ashkenazi research scientist 2012-2013 Genentech
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Publications

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Zhou HJ, Wang J, Yao B, et al. (2015) Discovery of a First-in-Class, Potent, Selective and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). Journal of Medicinal Chemistry
Anderson DJ, Le Moigne R, Djakovic S, et al. (2015) Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 28: 653-65
Yin Y, Djakovic S, Marsters S, et al. (2015) Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Anti-tumor Activity. Molecular Cancer Therapeutics
Dubinsky AN, Dastidar SG, Hsu CL, et al. (2014) Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metabolism. 20: 626-38
Djakovic SN, Marquez-Lona EM, Jakawich SK, et al. (2012) Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5126-31
Jakawich SK, Neely RM, Djakovic SN, et al. (2010) An essential postsynaptic role for the ubiquitin proteasome system in slow homeostatic synaptic plasticity in cultured hippocampal neurons. Neuroscience. 171: 1016-31
Djakovic SN, Schwarz LA, Barylko B, et al. (2009) Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II. The Journal of Biological Chemistry. 284: 26655-65
Cartier AE, Djakovic SN, Salehi A, et al. (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7857-68
Kerjan G, Koizumi H, Han EB, et al. (2009) Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proceedings of the National Academy of Sciences of the United States of America. 106: 6766-71
Dyachok J, Shao MR, Vaughn K, et al. (2008) Plasma membrane-associated SCAR complex subunits promote cortical F-actin accumulation and normal growth characteristics in Arabidopsis roots. Molecular Plant. 1: 990-1006
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