Junhwa Shin, Ph.D.

Affiliations: 
2002 Purdue University, West Lafayette, IN, United States 
Area:
Liposomes
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"Junhwa Shin"
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David H. Thompson grad student 2002 Purdue
 (Development of facile synthetic pathways to plasmenyl -type lipids and their utilization in the development of acid -sensitive vinyl ether-based pegylated liposomes.)
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Publications

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Shin J, Shum P, Grey J, et al. (2012) Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Molecular Pharmaceutics. 9: 3266-76
Van den Bossche J, Shin J, Thompson DH. (2007) Improved plasmalogen synthesis using organobarium intermediates. The Journal of Organic Chemistry. 72: 5005-7
van den Bossche J, Shin J, Shum P, et al. (2006) Design, synthesis and application of vinyl ether compounds for gene and drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: e1-3
Thompson DH, Shin J, Boomer J, et al. (2004) Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions. Methods in Enzymology. 387: 153-68
Shin J, Shum P, Thompson DH. (2003) Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids. Journal of Controlled Release : Official Journal of the Controlled Release Society. 91: 187-200
Shin J, Thompson DH. (2003) Direct synthesis of plasmenylcholine from allyl-substituted glycerols. The Journal of Organic Chemistry. 68: 6760-6
Shin J, Gerasimov O, Thompson DH. (2002) Facile synthesis of plasmalogens via Barbier-type reactions of vinyl dioxanes and vinyl dioxolanes with alkyl halides in LiDBB solution. The Journal of Organic Chemistry. 67: 6503-8
Shin J, Qualls MM, Boomer JA, et al. (2001) An efficient new route to plasmenyl-type lipids: synthesis and cytotoxicity of a plasmenylcholine analogue of the antitumor ether lipid ET-18-OMe. Journal of the American Chemical Society. 123: 508-9
Kim JM, Shin J, Shum P, et al. (2001) Acid- and oxidatively-labile vinyl ether surfactants: Synthesis and drug delivery applications Journal of Dispersion Science and Technology. 22: 399-407
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