Jenny L. Maki, Ph.D.

Affiliations: 
2009 Molecular & Cellular Biology University of Massachusetts, Amherst, Amherst, MA 
Area:
protein folding
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"Jenny Maki"
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Lila M. Gierasch grad student 2009 U Mass Amherst
 (The conformational gymnastics of the Escherichia coli SecA molecular machine and its interactions with signal sequences.)
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Publications

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Canning P, Ruan Q, Schwerd T, et al. (2015) Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chemistry & Biology. 22: 1174-84
Najjar M, Suebsuwong C, Ray SS, et al. (2015) Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Reports. 10: 1850-60
Degterev A, Zhou W, Maki JL, et al. (2014) Assays for necroptosis and activity of RIP kinases. Methods in Enzymology. 545: 1-33
Thapa RJ, Nogusa S, Chen P, et al. (2013) Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proceedings of the National Academy of Sciences of the United States of America. 110: E3109-18
Maki JL, Degterev A. (2013) Activity assays for receptor-interacting protein kinase 1:a key regulator of necroptosis. Methods in Molecular Biology (Clifton, N.J.). 1004: 31-42
Maki JL, Tres Brazell J, Teng X, et al. (2013) Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expression and Purification. 89: 156-61
Xie T, Peng W, Liu Y, et al. (2013) Structural basis of RIP1 inhibition by necrostatins. Structure (London, England : 1993). 21: 493-9
Degterev A, Maki JL, Yuan J. (2013) Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death and Differentiation. 20: 366
Maki JL, Smith EE, Teng X, et al. (2012) Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Analytical Biochemistry. 427: 164-74
Maki JL, Krishnan B, Gierasch LM. (2012) Using a low denaturant model to explore the conformational features of translocation-active SecA. Biochemistry. 51: 1369-79
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