Amber L. Southwell, Ph.D.
Affiliations: | 2017- | Burnett School of Biomedical Sciences-Neuroscience | University of Central Florida, Orlando, FL, United States |
Area:
Huntington disease, experimental therapeutics, transgenic mice, behavior, stem cellsWebsite:
https://med.ucf.edu/biomed/directory/dr-amber-southwell/Google:
"Amber Southwell"Mean distance: 14.39 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| David J. Anderson | grad student | 2001 | ||
| Erin M. Schuman | grad student | 2002 | ||
| Henry A. Lester | grad student | 2003 | ||
| Paul H. Patterson | grad student | 2009 | Caltech | |
| (Intrabodies as Therapeutics for Huntington's Disease.) | ||||
| Michael R. Hayden | post-doc | 2009-2016 | UBC | |
| (Huntington disease therapeutics) | ||||
BETA: Related publications
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Publications
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| Bartl S, Xie Y, Potluri N, et al. (2023) Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease. Neurobiology of Disease. 106376 |
| Rook ME, Southwell AL. (2022) Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 36: 105-119 |
| Caron NS, Banos R, Aly AE, et al. (2022) Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of Disease. 166: 105652 |
| Bhattacharyya A, Trotta CR, Narasimhan J, et al. (2021) Small molecule splicing modifiers with systemic HTT-lowering activity. Nature Communications. 12: 7299 |
| Ravalia AS, Lau J, Barron J, et al. (2021) Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice. Neurobiology of Disease. 105293 |
| Caron NS, Banos R, Yanick C, et al. (2020) Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Machiela E, Jeloka R, Caron NS, et al. (2020) The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons. Frontiers in Aging Neuroscience. 12: 524369 |
| Machiela E, Southwell AL. (2020) Biological Aging and the Cellular Pathogenesis of Huntington's Disease. Journal of Huntington's Disease |
| Bartl S, Oueslati A, Southwell AL, et al. (2020) Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease. Neurobiology of Disease. 104943 |
| Caron NS, Southwell AL, Brouwers CC, et al. (2019) Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease. Nucleic Acids Research |