Amber L. Southwell, Ph.D.

Affiliations: 
2017- Burnett School of Biomedical Sciences-Neuroscience University of Central Florida, Orlando, FL, United States 
Area:
Huntington disease, experimental therapeutics, transgenic mice, behavior
Website:
https://med.ucf.edu/biomed/directory/dr-amber-southwell/
Google:
"Amber Southwell"
Mean distance: 14.39 (cluster 11)
 
SNBCP

Parents

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David J. Anderson grad student 2001
Erin M. Schuman grad student 2002
Henry A. Lester grad student 2003
Paul H. Patterson grad student 2009 Caltech
 (Intrabodies as Therapeutics for Huntington's Disease.)
Michael R. Hayden post-doc 2009-2016 UBC
 (Huntington disease therapeutics)
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Publications

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Southwell AL, Kordasiewicz HB, Langbehn D, et al. (2018) Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease. Science Translational Medicine. 10
Ehrnhoefer DE, Martin DDO, Schmidt ME, et al. (2018) Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease. Acta Neuropathologica Communications. 6: 16
Ehrnhoefer DE, Southwell AL, Sivasubramanian M, et al. (2017) HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo. Human Molecular Genetics
Southwell AL, Skotte NH, Villanueva EB, et al. (2017) A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles. Human Molecular Genetics
Sanders SS, Parsons MP, Mui KK, et al. (2016) Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice. Bmc Biology. 14: 108
Southwell AL, Smith-Dijak A, Kay C, et al. (2016) An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes. Human Molecular Genetics
Connolly C, Magnusson-Lind A, Lu G, et al. (2016) Enhanced Immune Response to MMP3 stimulation in Microglia Expressing Mutant Huntingtin. Neuroscience
Miniarikova J, Zanella I, Huseinovic A, et al. (2016) Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease. Molecular Therapy. Nucleic Acids. 5: e297
Kay C, Collins JA, Skotte NH, et al. (2015) Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry. Molecular Therapy : the Journal of the American Society of Gene Therapy
Southwell AL, Smith SE, Davis TR, et al. (2015) Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression. Scientific Reports. 5: 12166
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